|
| Standard therapy | Adjuvant therapy | |||
| Adult | Child | Adult | Child | ||
| Simple case | · CHLOROQUINE PHOSPHATE 250 mg or CHLOROQUINE HYDROXIDE 200 mg tablet: 01 tablet every 12 h for 10 days · AZITHROMYCIN 250 mg tablet: 01 tablet every 12 hours (7 a.m. and 7 p.m.) on Day 1; 01 tablet per day at 7 a.m. from Day 2 to Day 5 · STAVIRAL (if contraindication to chloroquine): 02 tablets every 8 hours until cure · CEFIXIM 200 mg (if symptomatic): 01 tablet every 12 hours for 7 days | - CHLOROQUINE PHOSPHATE 250 mg: 5 mg/kg every 12 hours for 10 days - AZITHROMYCIN 250 mg tablet: 15 mg/kg at D1 either as a single dose or in two doses morning and evening; then 7.5 mg/kg at fixed time from D2 to D5 STAVIRAL SIROP | · VITAMIN C: 02 g/day · VITAMIN D: 4000 IU/day · ZINC: 45 mg/day for 10 days | - VITAMIN C: 250 mg/day for 10 days (under 7 years); 500 mg/day for 10 days (over 7 years) - ZINC: 10 mg/day for 10 days (under 6 months); 20 mg/day for 10 days (over 6 months) - VITAMIN D: 2000 IU/day | |
| Moderate case | · CHLOROQUINE PHOSPHATE 250 mg or CHLOROQUINE HYDROXIDE 200 mg tablet: 01 tablet every 12 h for 10 days · AZITHROMYCIN 250 mg tablet: 01 tablet every 12 hours (7 a.m. and 7 p.m.) on D1; 01 tablet per day at 7 a.m. from D2 to D5 · STAVIRAL: 02 tablets every 8 hours until recovery · CEFIXIM 200 mg: 01 tablet every 12 hours for 7 days · DEXAMETHASONE (if moderate case B): 20 mg/24 h during 5 days then stop if no signs of respiratory distress | · VITAMIN C: 02 g/day · VITAMIN D: 4000 IU/day · OMEPRAZOLE 40 mg: tablets if ulcer · ZINC: 45 mg/day for 10 days | |||
| Severe case | - LOPINAVIR/RITONAVIR tablet: 400 mg/100 mg every 12 h for 14 days - RIBAVIRINE injection tablet: 400 mg every 12 hours for 14 days - DEXAMETHASONE injection: 20 mg/8 h for 5 days, then 20 mg/12 h for 5 days, then 20 mg/24 h for 5 days - NB: the dose of DEXAMETHASONE may vary on a case-by-case basis depending on the evolution of the inflammatory process - STAVIRAL: 02 gelules/8 h until healing - ENOXAPARINE injection: at a preventive dose (0.4 ml/24 h) or curative dose (0.1 ml/kg/12 h) according to the thromboembolic risk NB: in case of renal insufficiency, use UFH/Calciparin - Antibiotic coverage · CEFTRIAXONE OR CEFOTAXIME: 02 g in IVD as a single injection for 3 days then relay with CEFIXIM 200 mg 01 table t/12 h · Imipenem 1 g/8 h + vancomycin 1 g in microinfusion of 1 h then 2 g in IVSE during 24 h in case of documented resistance - Anxiolytic and antidepressant (if necessary) · HYDROXYZINE: 50 - 100 mg/day in 02 doses · FLUVOXAMINE: 50 - 300 mg or FLUOXETINE (Prozac) 20 mg/day in case of major depressive episodes · PROMETHAZINE: 25 - 50 mg if insomnia is proven | · OMEPRAZOLE: 40 mg/day · ALBENDAZOLE: 400 mg to be repeated after 15 days · Potassium and calcium intake under control of the blood ionogram · VITAMIN C: 02 g/day · VITAMIN D: 4000 IU/day · ZINC: 45 mg/day for 10 days | |||