19 May 2014 ( one month after completion of chemotherapy)

Worsening of clinical condition of patients with complaints of diplopia and right sided Hemiparesis-anti oedema measures were started

Contrast MRI on subsequent day showed increased in the size of lesion measuring about 1.6 × 1.0 cm and 1.8 × 1.6 cm

Nimotuzumab 200 mg weekly IV was administered for 8 cycles

25 Aug 2014 (post 8 cycles of nimotuzumab)

Contrast MRI showed decrease in size of the lesion, measuring about 1.1 × 1.1 cm and 1.6 × 1.1 cm

Nimotuzumab was continued for additional 8 cycles of 200 mg weekly IV

2 October 2014 (post 8 cycles of nimotuzumab)

Contrast MRI showed that tumour size was further reduced, measuring about 1.2 × 1.0 cm and 1.0 × 1.2 cm

Nimotuzumab 200 mg three weekly for 4 cycles

10 February 2015

Patient stopped treatment voluntarily

10 October 2015

Patient presented with progressive symptoms. MRI showed two new lesions with largest lesion measuring 3 × 3.2 cm. PCV regimen, which was given for 3 cycle

3 February 2016

Death