| Structural domains of mutation | Mutation Code | Contacted Domains | Diseases Related |
| Piezo Repeat A | hR1955C | Beam | CAP |
| hA2020T | Piezo Repeat A | DHS | |
| hA2020V | Anchor | DHS | |
| Piezo Repeat A | |||
| hG2029R | Piezo Repeat A | GLD | |
| Inner Helix | hR2482H | Inner Helix | GLD |
| Anchor | |||
| CTD-IH Linkage | |||
| hR2456C | None | GLD | |
| hF2458L | Inner Helix | GLD | |
| Anchor | hA2003D | Piezo Repeat A | DHS |
| hT2127M | Anchor | DHS | |
| CTD | |||
| CTD | hR2488Q | CTD | DHS |
| Anchor | |||
| “Cap” | hM2225R | “Cap” | DHS |
| Beam | hR1358P | Beam | DHS |
| Piezo Repeat B | hV1712M | Piezo Repeat A | CAP |
| Piezo Repeat B | |||
| Outer Helix | hV2171F | Outer Helix | GLD |