| Position | Correspondent domain | Channel Function |
| 2500 - 2547 | CTD | Gating spring [3] [41] [42] [43] |
| 2486 - 2499 | CTD-IH Linkage | / |
| 2466 - 2485 | Inner Helix | Annular Lipids and Agonists [44] |
| 2456 - 2465 | Missing structure | / |
| 2218 - 2455 | “Cap” | Gating spring [3] [41] [42] [43] |
| Shear flow sensing [18] [25] | ||
| 2211 - 2217 | Missing Structure | / |
| 2184 - 2211 | Outer Helix | Annular Lipids and Agonists [44] |
| 2176 - 2183 | CTD-OH Linkage | / |
| 2106 - 2175 | Anchor | Annular lipids and agonists [44] |
| 1957 - 2105 | Piezo Repeat A | Hydrophobic mismatch by membrane curvature; |
| Hydrophobic mismatch by membrane thinning [45] [46] [47] [48] [49] | ||
| 1808 - 1956 | Missing Structure | / |
| 1657 - 1807 | Piezo Repeat B | Hydrophobic mismatch by membrane curvature; |
| Hydrophobic mismatch by membrane thinning [45] [46] [47] [48] [49] | ||
| 1418 - 1656 | Missing Structure | / |
| 1403 - 1417 | Latch | / |
| 1365 - 1402 | Missing Structure | / |
| 1300 - 1364 | Beam | Gating spring [3] [41] [42] [43] |
| 1137 - 1299 | Piezo Repeat C | Hydrophobic mismatch by membrane curvature; |
| Hydrophobic mismatch by membrane thinning [45] [46] [47] [48] [49] |