BC. December 1, 2009 PB, capecitabine, sorafenib, sirolimus, vorinostat

Regional radiology CT February 26, 2010

SD

KRAS-mutated, Molecular profiling-negative (blood)

12

Cancer institute March 25, 2005

Adenocarcinoma of the colon, invasive, moderately differentiated

Regional hospital CT March 2007

Para-aortic lymphadenopathy

Anterior resection of the colon February 3, 2005

FOLFOX May 2005-July 2005

Cancer institute October 24, 2007

Metastatic adenocarcinoma consistent with colorectal primary (retroauricular lymph node)

Irinotecan, capecitabine, BVZ November 2007 to March 2008

Dendritic cell vaccine March 2008

Cancer institute CT September 3, 2008

Recurrence (periaortic lymph nodes)

Irinotecan, capecitabine, oxaliplatin, BVZ to October 2009

Cancer institute PET/CT November 11, 2009

Recurrence (adrenal glands, lungs, stomach)

BC. January 19, 2010 PB, sorafenib, sirolimus, vorinostat, BVZ, panitumumab. Discontinued May 15, 2010

Regional radiology CT/PET June 15, 2010

SD

Molecular profiling-negative (blood)

13

Regional hospital April 27, 2007

Adenocarcinoma of the colon, poorly differentiated. Adenocarcinoma consistent with colorectal origin (liver biopsy)

Regional radiology PET/CT May 15, 2007

Small nodule in the left lower lobe of the lung

Transverse colon resection April 25, 2007

FOLFOX June 18, 2007 to November 26, 2007

Regional hospital CT May 12, 2009

Recurrence (liver)

Cetuximab July 2009 to September 2009

Resection of liver metastases September 24, 2009

Capecitabine and BVZ November 2009 to April 2010

Regional radiology PET/CT April 25, 2011

Recurrence (lungs)

Wedge resection of pulmonary nodules June 21, 2011

Regional radiology CT/PET July 19, 2011

Recurrence (lungs)

BC. August 29, 2011 PB, erlotinib, pazopanib, dasatinib

Regional radiology PET/CT November 22, 2011

SD

VEGF-elevated (blood), KRAS-R164Q mutation, equivalent to wild-type. IRS2-amplification APCR564 mutation, TP53 loss (R273H, R213) (Caris-tissue analysis)

14

Regional hospital March 27, 2006

Adenocarcinoma of the colon, moderately differentiated. KRAS wild-type

Regional radiology CT June 2008

Pulmonary nodule

Hemicolectomy March 23, 2006

FOLFOX June 2006 to December 2006

Regional radiology CT October 2008

Recurrence (lungs)