| Confirmation of diagnosis | Treatment | Confirmation of recurrence | Confirmation of response to PBT | Molecular profiling | |||||||
| Pathology | Radiology | ||||||||||
| Patient | Place and date | Diagnosis | Place and date | Diagnosis | Place and date | Assessment | Place and date | Assessment | |||
| RECURRENT (PERSISTENT) AFTER CHEMOTHERAPY AND RADIATION THERAPY | |||||||||||
| 1 | Regional medical center March 21, 2002 | Adenocarcinoma of the colon, moderately differentiated | Regional radiology CT September 19, 2002 | Metastatic lesions in the liver | Hemicolectomy and resection of the terminal ileum, cecum, ascending colon lymph nodes and a portion of the liver March 19, 2002 |
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| Regional medical center October 21, 2003 | Metastatic adenocarcinoma to the lung, moderately differentiated |
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| 5-FU and leucovorin. Radiofrequency ablation to the liver |
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| 5-FU and leucovorin September 24, 2003 to October 20, 2003 | Regional radiology PET September 24, 2003 | Recurrence |
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| 5-FU, leucovorin and oxaliplatin October 2003 to May 4, 2004 | Regional radiology PET May 4, 2004 | Recurrence |
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| BC. June 3, 2004 PB and trastuzumab |
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| Regional radiology CT November 9, 2004 | PD | HER-2-elevated (blood) | |
| 2 | Regional hospital October 5, 2004 | Adenocarcinoma of the colon, poorly differentiated | Regional radiology CT September 23, 2004 | Multiple liver metastases | Exploratory laparoscopy, right colectomy and ileo-transverse anastomosis September 30, 2004 | Cancer institute CT November 2, 2004 | Recurrence |
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| FOLFOX and BVZ November 9, 2004 to January 30, 2005 |
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| FOLFIRI February 28, 2005 to April 1, 2005 | Cancer institute CT April 25, 2005 | Recurrence |
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| Clinical trial with panitumumab May 19, 2005 to June 30, 2005 | Cancer institute CT July 12, 2005 | Recurrence |
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| Erbitux and irinotecan July 19, 2005 to August 16, 2005 | Cancer institute CT August 16, 2005 | Recurrence |
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| BC. September 13, 2005 PB, capecitabine, erlotinib |
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| Regional radiology CT November 7, 2005 | PD | HER-2-elevated (blood) | |
| 3 | Regional hospital January 7, 2004 | Adenocarcinoma of the colon, moderately differentiated | Regional hospital CT January 9, 2004 | Right hepatic lobe lesion | Right hemicolectomy January 5, 2004 |
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| FOLFOX January 29, 2004 to September 2004 |
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| Radiofrequency ablation of liver metastases September 16, 2004 |
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| FOLFIRI December 2004 to August 2005 | Regional radiology CT/PET February 17, 2005 | Recurrence |
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| Radiofrequency ablation March 29, 2005 | CT July 8, 2005 | Recurrence |
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