Study

Sample size

(Experimental/ control)

Intervation

Duration

Mean age (year)

Outcomes

Experimental

control

Expemental

control

Jun Y, 2008 [24]

15/16

BBR (0.5, tid)

Met (0.5, tid)

13 W

25 - 75

①②③⑤

Xue SX,

2012 (1) [25]

42/45

BBR (0.3, tid)

Met (0.75/d)

12 W

54 ± 11

①②③⑤

Zhang YD,

2012 [26]

38/38

BBR (0.5 - 0.8, tid)

Met (0.5, tid)

3 M

-

-

①②③⑤

Hao Z, 2010 [27]

50/26

BBR (1.0/d)

Met (1.5/d)

2 M

57 ± 8

56 ± 11

①②⑤

Cao Y, 2007 [28]

30/30

BBR (0.5, tid)

Met (0.5, tid)

3 M

55.3 ± 11.5

53.6 ± 12.9

①②③⑤

Li ML, 2008 (1) [29]

17/17

BBR (0.3, tid)

Met (0.5, tid)

12 W

61 ± 12

①②⑤

Liu ZM, 2013 [30]

36/32

BBR (0.3 - 0.5, tid)

+ Met (0.5, bid or increase slowly to 2.0/d)

Met (0.5, bid or increase slowly to 2.0/d)

16 W

56.5 ± 7.2

47.5 ± 6.5

①②③⑤

Xue SX, 2012 (2) [25]

44/45

BBR (0.45/d) + Met (0.75/d)

Met (0.75/d)

12 W

-

-

①②③

Zhou Q, 2012 [31]

46/46

BBR (0.2, tid) + Met (0.5, tid)

Met (0.5, tid)

12 W

44.67 ± 8.52

①②

Zhan HJ, 2015 [32]

40/40

BBR (0.2, tid) + Met (0.5, tid)

Met (0.5, tid)

3 M

51.6 ± 3.8

①②③④⑤

Lu LM, 2013 [33]

27/26

BBR (0.3, tid) + Met (0.5, bid)

Met (0.5, bid)

2 M

68 (43 - 79)

70 (46 - 82)

①②③

Jiang WL, 2019 [34]

51/51

BBR (0.3, tid) + Met (0.5, tid)

Met (0.5, tid)

12 W

63.19 ± 4.82

62.76 ± 4.59

①②③⑤

Yang X, 2020 [35]

96/96

BBR (0.3, tid) + Met (0.5 - 1.0, bid)

Met (0.5 - 1.0, bid)

3 M

49.9 ± 7.8

49.7 ± 7.4

①②③

Li ML, 2008 (2) [29]

18/17

BBR (0.3, tid) + Met (0.5, tid)

Met (0.5, tid)

12 W

61 ± 12

①②

Dong KL, 2017 [36]

49/49

BBR (0.3, tid) + Met (0.5, tid)

Met (0.5, tid)

12 W

51.34 ± 4.43

52.23 ± 4.41

①②③