Study | Sample size (Experimental/ control) | Intervation | Duration | Mean age (year) | Outcomes | ||
Experimental | control | Expemental | control | ||||
Jun Y, 2008 [24] | 15/16 | BBR (0.5, tid) | Met (0.5, tid) | 13 W | 25 - 75 | ①②③⑤ | |
Xue SX, 2012 (1) [25] | 42/45 | BBR (0.3, tid) | Met (0.75/d) | 12 W | 54 ± 11 | ①②③⑤ | |
Zhang YD, 2012 [26] | 38/38 | BBR (0.5 - 0.8, tid) | Met (0.5, tid) | 3 M | - | - | ①②③⑤ |
Hao Z, 2010 [27] | 50/26 | BBR (1.0/d) | Met (1.5/d) | 2 M | 57 ± 8 | 56 ± 11 | ①②⑤ |
Cao Y, 2007 [28] | 30/30 | BBR (0.5, tid) | Met (0.5, tid) | 3 M | 55.3 ± 11.5 | 53.6 ± 12.9 | ①②③⑤ |
Li ML, 2008 (1) [29] | 17/17 | BBR (0.3, tid) | Met (0.5, tid) | 12 W | 61 ± 12 | ①②⑤ | |
Liu ZM, 2013 [30] | 36/32 | BBR (0.3 - 0.5, tid) + Met (0.5, bid or increase slowly to 2.0/d) | Met (0.5, bid or increase slowly to 2.0/d) | 16 W | 56.5 ± 7.2 | 47.5 ± 6.5 | ①②③⑤ |
Xue SX, 2012 (2) [25] | 44/45 | BBR (0.45/d) + Met (0.75/d) | Met (0.75/d) | 12 W | - | - | ①②③ |
Zhou Q, 2012 [31] | 46/46 | BBR (0.2, tid) + Met (0.5, tid) | Met (0.5, tid) | 12 W | 44.67 ± 8.52 | ①② | |
Zhan HJ, 2015 [32] | 40/40 | BBR (0.2, tid) + Met (0.5, tid) | Met (0.5, tid) | 3 M | 51.6 ± 3.8 | ①②③④⑤ | |
Lu LM, 2013 [33] | 27/26 | BBR (0.3, tid) + Met (0.5, bid) | Met (0.5, bid) | 2 M | 68 (43 - 79) | 70 (46 - 82) | ①②③ |
Jiang WL, 2019 [34] | 51/51 | BBR (0.3, tid) + Met (0.5, tid) | Met (0.5, tid) | 12 W | 63.19 ± 4.82 | 62.76 ± 4.59 | ①②③⑤ |
Yang X, 2020 [35] | 96/96 | BBR (0.3, tid) + Met (0.5 - 1.0, bid) | Met (0.5 - 1.0, bid) | 3 M | 49.9 ± 7.8 | 49.7 ± 7.4 | ①②③ |
Li ML, 2008 (2) [29] | 18/17 | BBR (0.3, tid) + Met (0.5, tid) | Met (0.5, tid) | 12 W | 61 ± 12 | ①② | |
Dong KL, 2017 [36] | 49/49 | BBR (0.3, tid) + Met (0.5, tid) | Met (0.5, tid) | 12 W | 51.34 ± 4.43 | 52.23 ± 4.41 | ①②③ |