TANNINS

Maplexins A –I

(C₁₃H₁₆O₉)

Down-regulation of cyclins A and B1 and upregulating of cyclin E, cell-cycle arrest in S phase, induction of apoptosis via intrinsic pathway (FAS-independent, caspase 8-independent) through bcl-XL down-regulation with mitochondrial release of cytochrome c into the cytosol, activation of initiator caspase 9 and effector caspase-3.

HCT-116, Caco-2, CCD-112CoN

[147] [148]

Oral Cancer

FLAVONOIDS

Flavanones

(C₁₅H₁₀O₃)

Interaction with phase I metabolizing enzymes (e.g., cytochrome P450), which metabolically inactivate a large number of procarcinogens.

HSC-2, HSG, SCC-25

[149] [150] [151] [152] [153]

Isoflavonone

(C₁₅H₁₂O₂)

EGC

(C₁₅H₁₄O₇)

Chalcones

(C₁₅H₁₂O)

EGCG

(C₂₂H₁₈O₁₁)

Curcumin

(C₂₁H₂₀O₆)

Genistein

(C₁₅H₁₀O₅)

Quercetin,

(C₁₅H₁₀O₇)

Cisplatin

(C₂₀H₂₈N₁₂O₉PPt+)

TANNINS

Total Pomegranate Tannin (TPT) extract

Anti-proliferative activity

KB, CAL27

[147]

Lung Cancer

FLAVONOID

Flavone

(C₁₅H₁₀O₂)

Inhibition of tyrosine kinases.

SK-LU1, SW900, H441, H661, haGo-K-1, A549

[154] [155]

Quercetin

(C₁₅H₁₀O₇)

ALKALOID

Vinblastin

(C₄₆H₅₈N₄O₉)

Inhibition of cellular proliferation by altering the dynamics of tubulin addition and loss at the ends of mitotic spindle microtubules.

A549

[117] [119] [141] [156] [157]

Vincristine

(C₄₆H₅₆N₄O₁₀)

Taxol

(C₄₇H₅₁NO₁₄)

Camptothecin

(C₂₀H₁₆N₂O₄)