Functional Group

Incompatibilities

Type of Reaction

Primary amine

Mono and disaccharides

Amine-aldehyde and amine-acetal

Ester, cyclic lactose

Basic components

Ring opening, ester-base, hydrolysis

Carbonyl, hydroxyl

Silanol

Hydrogen bonding

Aldehyde

Amine, carbohydrates

Aldehyde-amine, Schiff base or glycosylamine formation

Carboxyl

Bases

Salt formation

Alcohol

Oxygen

Oxidation to aldehydes and ketones

Sulfhydryl

Oxygen

Dimerization

Phenol

Metals

Complexation

Glelatin capsule shell

Cationic surfactants

Denaturation