Catecholamine ROC variables

Symptom correlates (rho) at 95% confidence level.

1) Symptoms with significant correlates for both elevated NA, AD and DA, but DA correlates were lower.

Severity (SIR) (NA 0.575, AD 0.521) > DA 0.304

Delusions (n 133, NA 0.491, AD 0.418) > DA 0.344

2) Symptoms with significant positive correlates for NA and AD, but low DA correlates.

Poor attention (NA 0.488, AD 0.473) > DA 0.232

Abstract thinking impairment (NA 0.460, AD 0.405) > DA 0.272

Unusual thought (NA 0.447, AD 0.386) > DA 0.237

Self-neglect (NA 0.441, AD 0.419) > DA 0.250

Anxiety (NA 0.454, AD 0.418) > DA 0.234

Suicidality (AD 0.341, NA 0.308) > DA 0.198

3) Elevated NA n 133, rho 0.5, P, 0.0001 compared with weaker AD and DA

Cognitive disorganisation NA 0.583 > (AD 0.495 > DA 0.405)

Judgment and Insight impairment NA 0.580 > (NA 0.493 > DA 0.324)

SIR 0.575

Poor impulse control NA 0.575 > (AD 0.485 > DA 0.432)

Excitement NA 0.552 > (AD 0.437 > DA 0.366)

Suspiciousness NA 0.533 > (AD 0.458 > DA 0.299^*)

Hostility NA 0.517 > (AD 0.373 > DA 0.321)

Blunted affect NA 0.513 > (AD 0.441> DA 0.182^*)

Hallucinations NA 0.454 > (AD 0.397 > DA 0.219^*)

4) Strongest correlative strength is for adrenaline (AD) in a setting of weak dopamine correlate.

SIR 0.521

Emotional withdrawal AD 0.503 > NA 0.432 > DA 0.00^*

Suicidality AD 0.341, NA 0.308) > DA 0.198^*

5) Decreasing correlative strengths for dopamine (DA) n 133, (in a setting of strong NA and AD correlates demonstrating gradation from excitement to suicidality and emotional withdrawal.

Motor hyperactivity 0.451

Poor impulse control 0.432

Cognitive disorganisation 0.405

Excitement 0.366

Bizarre behaviour 0.363

Grandiosity 0.361

Elated mood 0.385

Hostility 0.321

Self-neglect 0.250

Unusual thought content 0.237

Anxiety 0.234

Judgment and Insight impairment 0.234

Poor attention 0.232

Suspiciousness 0.229

Hallucinations 0.219

Suicidality 0.198

Emotional withdrawal 0.00

6) Symptoms demonstrating an absence of significant correlates for the dopamine biomarker.

Emotional withdrawal, blunted affect, depressed mood, disturbed volition, motor retardation, passivity/apathy, symptom severity (SIR), lack of spontaneous conversation, stereotypic thinking, mannerisms and posturing, guilt, dissociative symptoms (experiencing blank periods, unreal feelings, being outside of oneself and other identities within self), ideas of reference and control, distractibility, thought pre-occupation, lack of spontaneous conversation, poor rapport, social avoidance and a history of abuse.

7) Symptoms with significant positive correlates for elevated dopamine biomarker.

Motor hyperactivity 0.345.

Elevated mood 0.258.

Grandiosity 0.243. Motor hyperactivity 0.345.

8) Symptoms with generalised low or absent correlates for all catecholamines.

Experiencing blank periods, (usually considered a dissociative symptom).