Behavioral task/indices

Paroxetine

Fluvoxamine

Clomipramine

Battery 1:

Sample size (drug/saline)

7/8

7/10

8/10

Body weight

ns

ns

ns

Home cage activity

ns

ns

ns

Open field test

Distance traveled

ns

ns

ns

Time center

↓

ns

ns

Light-dark box test

Distance traveled

ns

ns

ns

%Distance light

ns

↓

ns

%Time light

ns

↓ (trend)

ns

No. of transition

ns

ns

ns

First latency to enter dark

ns

ns

ns

Elevated plus maze test

Distance traveled

ns

ns

ns

%Time open

ns

ns

ns

%Number open

ns

ns

ns

Auditory startle response (and prepulse inhibition: PPI)

Startle response

ns

ns

ns

Startle threshold

ns

ns

ns

PPI

ns

ns

ns

Barnes maze test

Distance traveled

ns

ns

ns

Latency to enter

ns

ns

ns

No. of error

ns

ns

ns

Probe test

ns

ns

ns

Classical fear conditioning (freezing)

Conditioning

ns

ns

ns

Context test

ns

ns

ns

Cued test

ns

ns

↓

Battery 2:

Sample size (drug/saline)

9/10

4/6

10/10

Hole board test

Distance traveled

↓

↓

ns

Latency for head dipping

↑

ns

ns

Number of head dipping

ns

ns

ns

Duration for head dipping

ns

ns

ns

Duration of rearing

ns

ns

ns

Number of rearing

ns

ns

ns