Behavioral task/indices | Paroxetine | Fluvoxamine | Clomipramine | ||
Battery 1: |
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Sample size (drug/saline) | 7/8 | 7/10 | 8/10 | ||
Body weight | ns | ns | ns | ||
Home cage activity | ns | ns | ns | ||
Open field test |
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Distance traveled | ns | ns | ns | ||
Time center | ↓ | ns | ns | ||
Light-dark box test |
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Distance traveled | ns | ns | ns | ||
%Distance light | ns | ↓ | ns | ||
%Time light | ns | ↓ (trend) | ns | ||
No. of transition | ns | ns | ns | ||
First latency to enter dark | ns | ns | ns | ||
Elevated plus maze test |
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Distance traveled | ns | ns | ns | ||
%Time open | ns | ns | ns | ||
%Number open | ns | ns | ns | ||
Auditory startle response (and prepulse inhibition: PPI) |
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Startle response | ns | ns | ns | ||
Startle threshold | ns | ns | ns | ||
PPI | ns | ns | ns | ||
Barnes maze test |
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Distance traveled | ns | ns | ns | ||
Latency to enter | ns | ns | ns | ||
No. of error | ns | ns | ns | ||
Probe test | ns | ns | ns | ||
Classical fear conditioning (freezing) |
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Conditioning | ns | ns | ns | ||
Context test | ns | ns | ns | ||
Cued test | ns | ns | ↓ | ||
Battery 2: |
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Sample size (drug/saline) | 9/10 | 4/6 | 10/10 | ||
Hole board test |
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Distance traveled | ↓ | ↓ | ns | ||
Latency for head dipping | ↑ | ns | ns | ||
Number of head dipping | ns | ns | ns | ||
Duration for head dipping | ns | ns | ns | ||
Duration of rearing | ns | ns | ns | ||
Number of rearing | ns | ns | ns | ||