Covariates

No. of

Cases

No. of

Deaths

Joint Model

Relative Risk

(95% CI)

Association with derivative of albumin

Serum Albumin(t) (1-g/dL decrement)

1112

630

3.95 (3.18, 4.71)

Average Derivative of Serum Albumin (1-g/dL/month decrement)

1112

630

2.33 (1.40, 3.73)

Association with volatility of albumin

Baseline Albumin ( ${\beta }_{0i}^{\left(L\right)}$ ) (1-g/dL decrement)

1112

630

5.54 (4.19, 6.94)

${\kappa }_i^2{}^{\left(L\right)}$ (increase in volatility)

1112

630

1.23 (1.02, 1.41)

1: One may only consider the local effect of average serum albumin slope by computing the area under the derivative from 6 months prior to death up until the time of death.