Covariate of

Interest

True Parameter

Value

Two-Stage Cox

Joint Model

Mean

SD

MSE

Mean

SD

MSE

Case 1 - Uniform Weights

Albumin (t)

0.3

0.191

0.099

0.022

0.303

0.109

0.008

Area under the derivative curve (t)

0.5

0.346

0.179

0.053

0.449

0.188

0.030

Case 2 - Point-Wise Weights

Albumin (t)

0.3

0.142

0.095

0.033

0.261

0.104

0.009

d ( Albumin ( t ) ) d t

0.5

0.412

0.123

0.022

0.477

0.152

0.013