Type of application



Sofen et al., 2011 [29]


Clobetasol propionate and placebo

Treatment for up to four weeks is effective and well tolerated for moderate-to-severe plaque psoriasis of the scalp.

Olsen et al., 1991 [30]


Clobetasol propionate and placebo

Clobetasol propionate 0.05% scalp application appears to be a safe and an effective treatment for scalp psoriasis.

Jarratt et al., 2004 [31]


Clobetasol propionate and placebo

The shampoo formulation of clobetasol propionate is convenient and efficacious and minimizes systemic exposure while being efficient, safe and well-tolerated in the treatment of moderate to severe scalp psoriasis.

Franz et al., 2000 [32]


Clobetasol propionate and placebo

The results of the studies demonstrate that the enhancement of absorption induced by the foam vehicle also leads to an increase in efficacy. Data from 188 subjects show that those treated with clobetasol propionate (CP) foam experienced greater psoriatic improvement than subjects treated with a currently marketed solution product. For each of the signs and symptoms of psoriasis, as well as for the investigator’s global assessment, CP foam was found to be superior to CP solution.

Reygagne et al., 2002 [33]

Shampoo or gel

Clobetasol propionate and placebo

After 4 weeks of treatment, clobetasol proprionate 0.05%, shampoo was at least equivalent to the gel form and superior to its vehicle. The two active treatments were found to be equivalent safe.

Franz et al., 1999 [34]


Betamethasone valerate and placebo

This formulation has increased efficacy in the treatment of scalp psoriasis without an associated increase in toxicity.

Medansky and Handler, 1974 [35]



valerate and placebo

The lotion with betamethasone was more them the vehicle.

Betamethasone valerate and placebo

Tyring et al., 2010 [36]


Calcipotriol and betamethasone dipropionate with placebo

Calcipotriol and betamethasone dipropionate was significantly superior to placebo. 71.9% of patients had cleared ou minimal disease after 8 weeks of treatment.

Harris, 1972 [37]

Lotion (alcoholic)

Valerate betamethasone with placebo

Significant differences were found to exist in favor of betamethasone valerate lotion 0.1% in lichenification, excoriation, inflammation, scaling and pruritus than vehicle group.

Jemec et al., 2008 [38]


Two active ingredients (calcipotriol and betamethasone dipropionate) with each one active ingredients separately and with placebo

The two active ingredients formula was superior to placebo and both of the active ingredients separately. Adverse effects were similar in the two compound group and betamethasone group and significantly smaller than calcipotriol group and placebo group.

Green et al., 1994 [39]


Calcipotriol with placebo

Calcipotriol was significantly superior to placebo in reducing redness, thickness, scaliness and extent of psoriasis, and in the patients’ assessment in reducing scalp flaking and itching. No statistically significant changes in blood biochemistry were detected during the study, and the solution was generally well tolerated.

Pauporte et al., 2004 [40]

Topical oil

Fluocinolone acetonide with placebo

It is shown that fluocinolone acetonide (FA) in an oil base that aids in the softening of the skin and allows penetration of the steroid into the stratum corneum, is an effective treatment for psoriasis of the scalp. This study also showed that the vehicle alone causes an improvement in the signs of psoriasis, but that the addition of 0.1% of the low potency steroid, FA leads to a significantly better improvement.