| Parameters | ENISA | NIST | OTT |
| Scope | Broad coverage of cybersecurity threats, including healthcare-specific ones. | General framework applicable to various sectors, including healthcare | Comprehensive coverage, especially for industrial automation and control systems |
| Granularity | Detailed threat descriptions, suitable for in-depth analysis. | Balanced approach, neither too detailed nor too high-level | Focus on technical threats, may lack granularity in non-technical aspects |
| Emerging Threats | May not cover the latest emerging threats comprehensively | Provides guidelines for managing evolving risks | May need updates to address emerging healthcare threats |
| Applicability | Suitable for healthcare but requires tailoring | Relevant for healthcare but not specific to the industry | May need customization for healthcare context |
| Alignment with Standards | May align with ISO/IEC 27001 and other standards | Provides overall direction for securing Operational Technology systems | Specific focus on industrial automation security |
| User-Friendliness | May be complex due to extensive categorization | Balanced and practical for various users | Depends on user familiarity with industrial control systems |
| Privacy considerations | May need additional privacy-specific criteria | Addresses privacy but not healthcare-specific privacy concerns | Privacy aspects may need customization |
| Resource requirements | May require significant resources for implementation | Balanced approach considering resource constraints | Resource-efficient but may need adaptation |