Behavioral Interventions | ||||
Reich et al. [119] | Randomized, controlled trial | Mindfulness-Based Stress Reduction (MBSR) | BC patients (n = 322), 35.7% of which have received chemotherapy + radiotherapy | - Immediately following a six-week MBSR program, no significant change was observed in cognitive performance compared with usual care, as measured by the Everyday Cognition scale (ECog) |
Dobos et al. [120] | Prospective single-arm cohort study | Mindfulness-Based Stress Reduction (MBSR) | Cancer patients (n = 117), of which 65% were diagnosed with BC and 48.72% had received chemotherapy. | - Immediately following an eleven-week MBSR program, significant improvement was observed in the cognitive subset of the European organization for research and treatment of cancer quality of life questionnaire (EORTC QLQ-C30). (p = 0.001) - Results were sustained at the three-month follow up period (p = 0.001) |
Fernandes et al. [122] | Systematic review of 19 studies (12 randomized controlled trials, 3 non-randomized controlled trials, 4 single arm studies). | Cognitive rehabilitation | Patients with various solid and hematological malignancies; 11 studies recruited only BC patients; BC was the most common diagnosis across all studies. The vast majority of BC patients had received prior chemotherapy. | - All included studies found significant improvement in at least one cognitive domain following a cognitive rehabilitation intervention, either objectively-assessed or self-reported. - Objective improvement in memory was the most frequently reported finding. |
Oberste et al. [124] | Single-blinded randomized controlled trial *** | High Intensity Interval Endurance Training (HIIT) | BC patients (n = 59) currently undergoing first-line chemotherapy, concurrently with a HIIT program or a placebo program (myofascial release training) | - Change in cognitive performance from baseline to the end of the HIIT intervention will be assessed using the Hopkins Verbal Learning Test, Controlled Oral Word Association Test and the Trail-Making-Test
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