Pharmacologic Interventions, Pre-Clinical Studies | |||
Reference | Intervention Investigated | Animal Model | Findings |
Tangpong et al. [85] | Anti-TNF antibody | Mice treated with systemic doxorubicin (intraperitoneal injection) with/without anti-TNF antibody | - TNF levels in brain tissue were significantly elevated following doxorubicin treatment (p < 0.01) - Measures of brain mitochondrial function were significantly reduced following doxorubicin treatment (p < 0.05) - Anti-TNF antibody administration prevented the increase of central TNF levels, as well as the decline in mitochondrial function |
Keeney et al. [88] | 2-mercaptoethanesulfonate sodium (MESNA) | Mice treated with systemic doxorubicin (intraperitoneal injection) with/without MESNA | - Indicators of oxidative stress (protein carbonyl, protein-bound 4-hydroxynonenal) were significantly elevated in the sera and brain tissue of mice following doxorubicin administration (brain: p < 0.01; sera: p < 0.0001 for protein carbonyl, p < 0.001 for protein-bound 4-hydroxynonenal) - Novel Object Recognition (NOR) was significantly reduced in doxorubicin-treated mice (p < 0.05) - MESNA administration before and after doxorubicin ameliorated the rise of oxidative stress measures in brain (p < 0.01) and sera (p < 0.01 for protein carbonyl, p < 0.05 for protein-bound 4-hydroxynonenal) - MESNA administration prevented the doxorubicin- induced deterioration in NOR |
Zhou et al. [106] | Metformin | Mice intra-peritoneally treated with cisplatin with/without metformin | - Exposure to cisplatin significantly reduced performance in the Novel Object and Place Recognition Test (NOPRT) (p < 0.05), an effect that was not exhibited in subjects treated concurrently with metformin |