| Cytogenetic Markers |
Pediatric T-ALL |
|
Adult T-ALL |
|
||||||||||
| Ploidy |
Ploidy |
|||||||||||||
| Hypodiploidy |
Diploidy |
Hyperdiploidy |
Hypodiploidy |
Diploidy |
Hyperdiploidy |
|||||||||
| Pos |
Neg |
Pos |
Neg |
Pos |
Neg |
p-value |
Pos |
Neg |
Pos |
Neg |
Pos |
Neg |
p-value |
|
| del(9p) |
20 20% |
24 20% |
72 67% |
86 70% |
14 13% |
13 10% |
0.826 |
32 27% |
26 16% |
73 63% |
107 66% |
12 10% |
29 18% |
0.03 |
| MLL translocations |
2 18% |
43 20% |
9 82% |
142 67% |
0 0% |
27 13% |
0.414 |
2 33% |
51 22% |
4 67% |
141 62% |
0 0% |
37 16% |
0.519 |
| TCRα, TCRβ, TLX1, TLX3 |
18 22% |
25 19% |
54 67% |
88 69% |
9 11% |
15 12% |
0.895 |
21 25% |
35 19% |
57 67% |
116 63% |
7 8% |
32 18% |
0.111 |
| Age 1 - 10 years
11 - 15 years
|
- 21 47% - 24 53% |
- - |
- 91 56% - 70 44% |
- |
- 16 59% - 11 41% |
- |
0.447 - - - - - |
<40 years 50 86% >40 years 8 14% |
- |
161 88%
21 12% |
- |
32 78%
9 22% |
- |
0.212 - - - - - |