| Cytogenetic Markers |
Pediatric BCP-ALL |
|
Adult BCP-ALL |
|
||||||
| Ploidy |
Ploidy |
|||||||||
| Diploidy |
Hyperdiploidy |
Diploidy |
Hyperdiploidy |
|||||||
| Pos |
Neg |
Pos |
Neg |
p-value |
Pos |
Neg |
Pos |
Neg |
p-value |
|
| +4, +10, +17 |
23 (6%) |
395 (79%) |
374 (94%) |
103 (21%) |
0.0005 |
10 (13%) |
241 (81%) |
65 (87%) |
57 (19%) |
0.0005 |
| +21 |
85 (11%) |
817 (80%) |
677 (89%) |
201 (20%) |
0.0005 |
- |
- |
- |
- |
- |
| t(9;22) |
66 (80%) |
856 (50%) |
17 (20%) |
864 (50%) |
0.0005 |
167 (78%) |
450 (70%) |
47 (22%) |
192 (30%) |
0.007 |
| t(12;21) |
152 (65%) |
764 (49%) |
83 (35%) |
797 (51%) |
0.0005 |
- |
- |
- |
- |
- |
| MLL translocations |
43 (86%) |
879 (50%) |
7 (14%) |
873 (50%) |
0.0005 |
13 (72%) |
603 (72%) |
5 (28%) |
234 (28%) |
0.987 |
| t(1;19) |
121 (79%) |
792 (49%) |
33 (21%) |
833 (51%) |
0.0005 |
33 (75%) |
573 (72%) |
11 (25%) |
222 (28%) |
0.673 |
| Age 1 - 10 years 11 - 15 years |
- 690 (47%) 232 (69%) |
- |
- 778 (53%) 103 (31%) |
- |
- 0.0005 |
<40 years 477 (72%) >40 years 140 (73%) |
- |
- 189 (28%) 51 (27%) |
- |
0.649 |