Cytogenetic Markers

Pediatric BCP-ALL

p-value

Adult BCP-ALL

p-value

Age

Age

1 - 10 years

11 - 15 years

<40 years

>40 years

Pos

Neg

Pos

Neg

Pos

Neg

Pos

Neg

+4, +10, +17

368 (90%)

428 (74%)

39 (10%)

151 (26%)

0.0005

64 (77%)

273 (78%)

19 (23%)

77 (22%)

0.826

t(9;22)

90 (58%)

1803 (80%)

65 (42%)

448 (20%)

0.0005

235 (66%)

755 (80%)

122 (34%)

186 (20%)

0.0005

t(12;21)

271 (93%)

1613 (77%)

20 (7%)

488 (23%)

0.0005

-

-

-

-

-

MLL translocations

66 (89%)

1825 (78%)

8 (11%)

505 (22%)

0.025

22 (71%)

967 (77%)

9 (29%)

297 (23%)

0.474

t(1;19)

127 (75%)

1737 (79%)

42 (25%)

456 (21%)

0.213

51 (91%)

922 (76%)

5 (9%)

290 (24%)

0.009