| Adult BCP-ALL |
Pediatric BCP-ALL |
|||||||
| Cytogenetic Markers |
Frequency |
Frequency |
||||||
| Present Study |
Western population |
Asian population |
Present Study |
Western population |
Asian population |
|||
| China |
Japan |
China |
Japan |
|||||
| Hyperdiploid High Hyperdiploidy Low Hyperdiploidy |
24% 9% 15% |
7% - 10% - - |
3% - - |
- - - |
44% 27% 17% |
25% - 30% - - |
12% - - |
- |
| Tri-tetraploidy |
2.5% |
1% |
- |
- |
2% |
1% |
- |
- |
| Hypodiploidy Low Hypodiploidy High Hypodiploidy |
13% 4% 9% |
1% - 3% - - |
2% - - |
- - - |
8% 2% 6% |
2% - 5% - - |
3% - - |
- |
| Haploidy |
0.5% |
1>% |
- |
- |
0.3% |
1>% |
- |
- |
| +4, +10, +17 |
19% |
- |
- |
- |
41% |
40% - 65% |
- |
- |
| t(9;22) |
27% |
25% - 30% |
28% |
7% |
6% |
2% - 5% |
6% |
3% |
| t(12;21) |
0.2% |
2% - 3% |
0% |
5% |
12.2% |
20% - 25% |
13% - 19% |
13% |
| (iAMP21) |
0.4% |
- |
- |
3% |
1% |
1% - 3% |
- |
2% |
| t(1;19) |
4% |
3% |
1% |
5% |
7% |
5% - 6% |
3% |
6% |
| t(17;19) |
- |
- |
- |
- |
0.6% |
- |
- |
- |
| MLL translocations |
2.4% |
5% - 10% |
2% |
3% |
3% |
5% - 8% |
1.5% |
1.6% |