|
| 1 mg/Kg bwt | 137.21 ± 22.11 (1.00) | 165.85 ± 29.91 (1.00) | 99.03 ± 18.86 (1.00) |
|
| 5 mg/Kg bwt | 149.19 ± 33.32 (1.00) | 121.88 ± 21.33 (1.00) | 176.1 ± 43.4 (0.86) |
|
| 20 mg/Kg bwt | 152.01 ± 33.01 (1.00) | 171.74 ± 47.17 (1.00) | 119.1 ± 43.3 (1.00) |
|
| 500 mg/Kg bwt | 221.65 ± 60.60 (0.53) | 207.90 ± 87.10 (0.96) | 235.4 ± 118.6 (0.59) |
|
| Ref. range | 16 - 48 | 18 - 45 | 16 - 48 |
|
| ANOVA p-value | 0.56 | 0.80 | 0.50 |
| AST (U/L) |
|
|
|
|
|
| Control | 281.6 ± 87.5 | 347.2 ± 106.2 | 183.1 ± 162.8 |
|
| 1 mg/Kg bwt | 370.2 ± 77.2 (0.99) | 421.0 ± 119.3 (0.96) | 293.9 ± 84.6 (1.00) |
|
| 5 mg/Kg bwt | 415.43 ± 133.44 (0.97) | 314.5 ± 113.1 (0.98) | 516.4 ± 271.4 (0.90) |
|
| 20 mg/Kg bwt | 507.8 ± 147.4 (0.78) | 543.5 ± 264.1 (0.75) | 454.4 ± 56.8 (0.95) |
|
| 500 mg/Kg bwt | 631.8 ± 261.4 (0.47) | 475.0 ± 315.0 (0.98) | 788.7 ± 511.4 (0.57) |
|
| Ref. range | 65 - 203 | 74 - 143 | 65 - 203 |
|
| ANOVA p-value | 0.52 | 0.92 | 0.61 |
| TP (g/dL) |
|
|
|
|
|
| Control | 7.08 ± 0.08 | 7.12 ± 0.042 | 7.03 ± 0.20 |
|
| 1 mg/Kg bwt | 7.93 ± 0.19 (0.004*) | 7.68 ± 0.12 (0.03*) | 8.27 ± 0.36 (0.03*) |
|
| 5 mg/Kg bwt | 7.77 ± 0.13 (0.02*) | 7.88 ± 0.12 (0.004*) | 7.60 ± 0.24 (0.37) |
|
| 20 mg/Kg bwt | 8.17 ± 0.14 (<0.0001***) | 7.97 ± 0.14 (0.001*) | 8.50 ± 0.15 (0.01*) |
|
| 5000 mg/Kg bwt | 6.65 ± 0.28 (0.45) | 7.13 ± 0.08 (1.00) | 6.18 ± 0.35 (0.27) |
|
| Ref. range | 5.2 - 7.7 | 5.2 - 7.1 | 5.5 - 7.7 |
|
| ANOVA p-value | <0.0001*** | <0.0001*** | 0.001*** |
| Urea (mmol/L) |
|
|
|
|
|
| Control | 7.76 ± 0.49 | 6.91 ± 0.20 | 8.88 ± 0.69 |
|
| 1 mg/Kg bwt | 10.17 ± 1.07 (0.31) | 9.79 ± 1.42 (0.18) | 10.67 ± 1.95 (0.94) |
|
| 5 mg/Kg bwt | 9.85 ± 0.51 (0.42) | 9.76 ± 0.93 (0.18) | 9.94 ± 0.59 (1.00) |
|
| 20 mg/Kg bwt | 11.21 ± 1.19 (0.05*) | 10.06 ± 0.47 (0.09) | 13.13 ± 3.10 (0.45) |
|
| 5000 mg/Kg bwt | 7.77 ± 0.42 (1.00) | 7.76 ± 0.80 (0.99) | 7.88 ± 0.64 (1.00) |
|
| Ref. range | 4.43 - 9.76 | 4.43 - 8.86 | 4.75 - 9.76 |
|
| ANOVA p-value | 0.04* | 0.07 | 0.37 |
| DBil (μmol/L) |
|
|
|
|
|
| Control | 1.65 ± 0.21 | 1.37 ± 0.19 | 1.93 ± 0.33 |
|
| 1 mg/Kg bwt | 2.07 ± 0.11 (1.00) | 1.95 ± 0.18 (0.70) | 2.23 ± 0.09 (1.00) |
|
| 5 mg/Kg bwt | 2.24 ± 0.23 (1.00) | 1.88 ± 0.27 (0.79) | 2.60 ± 0.29 (1.00) |
|
| 20 mg/Kg bwt | 4.86 ± 2.33 (0.31) | 2.85 ± 0.47 (0.04*) | 7.53 ± 5.59 (0.54) |
|
| 5000 mg/Kg bwt | 1.48 ± 0.23 (1.00) | 1.25 ± 0.25 (1.00) | 1.70 ± 0.40 (1.00) |
|
| Ref. range | 0.51 - 1.03 | 0.51 - 0.85 | 0.51 - 1.03 |
|
| ANOVA p-value | 0.25 | 0.003* | 0.50 |