1 mg/Kg bwt

137.21 ± 22.11 (1.00)

165.85 ± 29.91 (1.00)

99.03 ± 18.86 (1.00)

5 mg/Kg bwt

149.19 ± 33.32 (1.00)

121.88 ± 21.33 (1.00)

176.1 ± 43.4 (0.86)

20 mg/Kg bwt

152.01 ± 33.01 (1.00)

171.74 ± 47.17 (1.00)

119.1 ± 43.3 (1.00)

500 mg/Kg bwt

221.65 ± 60.60 (0.53)

207.90 ± 87.10 (0.96)

235.4 ± 118.6 (0.59)

Ref. range

16 - 48

18 - 45

16 - 48

ANOVA p-value

0.56

0.80

0.50

AST (U/L)

Control

281.6 ± 87.5

347.2 ± 106.2

183.1 ± 162.8

1 mg/Kg bwt

370.2 ± 77.2 (0.99)

421.0 ± 119.3 (0.96)

293.9 ± 84.6 (1.00)

5 mg/Kg bwt

415.43 ± 133.44 (0.97)

314.5 ± 113.1 (0.98)

516.4 ± 271.4 (0.90)

20 mg/Kg bwt

507.8 ± 147.4 (0.78)

543.5 ± 264.1 (0.75)

454.4 ± 56.8 (0.95)

500 mg/Kg bwt

631.8 ± 261.4 (0.47)

475.0 ± 315.0 (0.98)

788.7 ± 511.4 (0.57)

Ref. range

65 - 203

74 - 143

65 - 203

ANOVA p-value

0.52

0.92

0.61

TP (g/dL)

Control

7.08 ± 0.08

7.12 ± 0.042

7.03 ± 0.20

1 mg/Kg bwt

7.93 ± 0.19 (0.004*)

7.68 ± 0.12 (0.03*)

8.27 ± 0.36 (0.03*)

5 mg/Kg bwt

7.77 ± 0.13 (0.02*)

7.88 ± 0.12 (0.004*)

7.60 ± 0.24 (0.37)

20 mg/Kg bwt

8.17 ± 0.14 (<0.0001***)

7.97 ± 0.14 (0.001*)

8.50 ± 0.15 (0.01*)

5000 mg/Kg bwt

6.65 ± 0.28 (0.45)

7.13 ± 0.08 (1.00)

6.18 ± 0.35 (0.27)

Ref. range

5.2 - 7.7

5.2 - 7.1

5.5 - 7.7

ANOVA p-value

<0.0001***

<0.0001***

0.001***

Urea (mmol/L)

Control

7.76 ± 0.49

6.91 ± 0.20

8.88 ± 0.69

1 mg/Kg bwt

10.17 ± 1.07 (0.31)

9.79 ± 1.42 (0.18)

10.67 ± 1.95 (0.94)

5 mg/Kg bwt

9.85 ± 0.51 (0.42)

9.76 ± 0.93 (0.18)

9.94 ± 0.59 (1.00)

20 mg/Kg bwt

11.21 ± 1.19 (0.05*)

10.06 ± 0.47 (0.09)

13.13 ± 3.10 (0.45)

5000 mg/Kg bwt

7.77 ± 0.42 (1.00)

7.76 ± 0.80 (0.99)

7.88 ± 0.64 (1.00)

Ref. range

4.43 - 9.76

4.43 - 8.86

4.75 - 9.76

ANOVA p-value

0.04*

0.07

0.37

DBil (╬╝mol/L)

Control

1.65 ± 0.21

1.37 ± 0.19

1.93 ± 0.33

1 mg/Kg bwt

2.07 ± 0.11 (1.00)

1.95 ± 0.18 (0.70)

2.23 ± 0.09 (1.00)

5 mg/Kg bwt

2.24 ± 0.23 (1.00)

1.88 ± 0.27 (0.79)

2.60 ± 0.29 (1.00)

20 mg/Kg bwt

4.86 ± 2.33 (0.31)

2.85 ± 0.47 (0.04*)

7.53 ± 5.59 (0.54)

5000 mg/Kg bwt

1.48 ± 0.23 (1.00)

1.25 ± 0.25 (1.00)

1.70 ± 0.40 (1.00)

Ref. range

0.51 - 1.03

0.51 - 0.85

0.51 - 1.03

ANOVA p-value

0.25

0.003*

0.50