Dapagliflozin
From/to	CKD 1		CKD 2		CKD 3a		CKD 3b		CKD 4		CKD 5		Dialysis		Transplantation		Ref.
From/to	Mean	SE	Mean	SE	Mean	SE	Mean	SE	Mean	SE	Mean	SE	Mean	SE	Mean	SE
Month 0 - 4
CKD 1	0.586	0.076	0.219	0.064	0.049	0.033	0.049	0.033	0.024	0.024	0.024	0.024	0.024	0.024	0.025	0.024	[14]
CKD 2	0.018	0.005	0.709	0.016	0.246	0.015	0.019	0.005	0.003	0.002	0.003	0.002	0.001	0.001	0.001	0.001	[14]
CKD 3a	0.001	0.001	0.079	0.006	0.749	0.009	0.162	0.008	0.008	0.002	0	0	0	0	0	0	[14]
CKD 3b	0.001	0	0.005	0.001	0.079	0.004	0.812	0.006	0.102	0.005	0.001	0	0	0	0	0	[14]
CKD 4	0.001	0.001	0.003	0.001	0.006	0.002	0.143	0.008	0.843	0.008	0.004	0.001	0.001	0.001	0.001	0	[14]
CKD 5	0.063	0.06	0.125	0.08	0.062	0.058	0.124	0.08	0.375	0.118	0.125	0.08	0.063	0.059	0.062	0.059	[14]
Dialysis	0	0	0	0	0	0	0	0	0	0	0	0	0.995	0.0995	0.005	0.0005	[17]
Transplantation	0	0	0	0	0	0	0	0	0	0	0	0	0.007	0.0007	0.993	0.0993	[17]
Month 5 & on
CKD 1	0.891	0.017	0.07	0.014	0.009	0.005	0.015	0.007	0.006	0.004	0.003	0.003	0.003	0.003	0.003	0.003	[14]
CKD 2	0.005	0.001	0.909	0.004	0.078	0.004	0.006	0.001	0.002	0.001	0	0	0	0	0	0	[14]
CKD 3a	0.001	0	0.025	0.001	0.913	0.003	0.059	0.002	0.002	0	0	0	0	0	0	0	[14]
CKD 3b	0	0	0.001	0	0.025	0.001	0.938	0.002	0.035	0.001	0	0	0	0	0	0	[14]
CKD 4	0	0	0	0	0.001	0	0.035	0.002	0.952	0.002	0.01	0.001	0.001	0	0	0	[14]
CKD 5	0.001	0.001	0.002	0.001	0.002	0.001	0.001	0.001	0.027	0.005	0.92	0.008	0.045	0.006	0.002	0.001	[14]
Dialysis	0	0	0	0	0	0	0	0	0	0	0	0	0.995	0.0995	0.005	0.0005	[17]
Transplantation	0	0	0	0	0	0	0	0	0	0	0	0	0.007	0.0007	0.993	0.0993	[17]
Standard of care (SOC)
From/to	CKD 1		CKD 2		CKD 3a		CKD 3b		CKD 4		CKD 5		Dialysis		Transplantation		Ref.
From/to	Mean	SE	Mean	SE	Mean	SE	Mean	SE	Mean	SE	Mean	SE	Mean	SE	Mean	SE
Month 0 - 4
CKD 1	0.375	0.084	0.313	0.081	0.156	0.064	0.031	0.03	0.031	0.03	0.031	0.03	0.031	0.03	0.031	0.03	[14]
CKD 2	0.009	0.003	0.77	0.014	0.195	0.013	0.015	0.004	0.004	0.002	0.002	0.002	0.002	0.002	0.001	0.001	[14]
CKD 3a	0.002	0.001	0.07	0.005	0.774	0.009	0.149	0.007	0.004	0.001	0	0	0	0	0	0	[14]
CKD 3b	0.002	0.001	0.004	0.001	0.084	0.005	0.826	0.006	0.082	0.005	0.001	0.001	0.001	0	0	0	[14]
CKD 4	0.001	0.001	0.002	0.001	0.005	0.002	0.127	0.008	0.856	0.009	0.007	0.002	0.001	0.001	0.001	0.001	[14]
CKD 5	0.043	0.041	0.174	0.077	0.043	0.042	0.044	0.042	0.175	0.077	0.348	0.097	0.13	0.068	0.043	0.041	[14]
Dialysis	0	0	0	0	0	0	0	0	0	0	0	0	0.995	0.0995	0.005	0.0005	[17]
Transplantation	0	0	0	0	0	0	0	0	0	0	0	0	0.007	0.0007	0.993	0.0993	[17]
Month 5 & on
CKD 1	0.884	0.02	0.075	0.016	0.015	0.007	0.011	0.006	0.004	0.004	0.004	0.004	0.004	0.004	0.004	0.004	[14]
CKD 2	0.004	0.001	0.915	0.004	0.072	0.004	0.008	0.001	0.002	0.001	0	0	0	0	0	0	[14]
CKD 3a	0	0	0.023	0.001	0.91	0.003	0.064	0.002	0.003	0.001	0	0	0	0	0	0	[14]
CKD 3b	0	0	0.001	0	0.026	0.001	0.931	0.002	0.041	0.001	0	0	0.001	0	0	0	[14]
CKD 4	0	0	0.001	0	0.001	0	0.028	0.001	0.954	0.002	0.014	0.001	0.002	0	0	0	[14]
CKD 5	0.001	0.001	0.001	0.001	0.001	0.001	0.002	0.001	0.038	0.005	0.91	0.008	0.044	0.005	0.003	0.002	[14]
Dialysis	0	0	0	0	0	0	0	0	0	0	0	0	0.995	0.0995	0.005	0.0005	[17]
Transplantation	0	0	0	0	0	0	0	0	0	0	0	0	0.007	0.0007	0.993	0.0993	[17]