| Study (Year) | No. of eyes | No. of successful catheterizations (%success rate) | Drugs + Adjunct treatment | Indication (No. of eyes) | Overall eyeball salvage | Eyeball salvage by group | Ocular complications | Systemic complications | Metastasis | Death | |||||||||||||||||||
| David Abramson et al. (2016) [26] | 112 | NA | M, T, C | Primary (85.1) Bridge (85.7%)** Secondary (72.4%) | 74% | 74% group D | Eyelid edema Madarosis Retinal or choroidal vascular occlusion Phthisis Vitreous hemorrhage Ptosis Optic nerve swelling Retinopathy Cranial nerve palsy Ophthalmic artery vessel injury or sclerosis Suprachoroidal hemorrhage | Neutropenia Bronchospasm Allergy reaction Thrombocytopenia Fever Cardiorespiratory side effects Injection site complications (bleeding or thrombosis) Epistaxis | 3 | 1 | |||||||||||||||||||
| Chee Chung Liu et al. (2020) | 14 | 23/32 (71.8%) | M | Primary (7%), secondary (93%) | 38% | NA | Eyelid edema Conjunctiva chemosis Ophthalmic artery dissection Ophthalmic artery occlusion Retina artery occlusion Optic atrophy | Bronchospasm Hematoma | 0 | 0 | |||||||||||||||||||
| Miaojuan Chen et al. (2017) | 107 | 338/343 (98.5%) | M, T | Primary (28.1%) Secondary (71.9%) | 78.5% | Group B (100%), Group C (100%), Group D (78.6%), and Group E (62%) | Eyelid edema Bulbar conjunctiva congestion Excessive tearing Vitreous hemorrhage Subretinal hemorrhage Retinal vasculopathy Ophthalmic artery spasm | Fever Transient vomiting Transient myelosuppression | NA | NA | |||||||||||||||||||
| Pukhraj Rishi et al. (2019) | 15 | NA | M, T + VEC + TTT + IVitC + Cryo | Primary (6) Secondary (9) | 67% | Group B (100%) Group C, (67%), Group D (67%), Group E (50%) | Posterior subcapsular cataract Vitreous hemorrhage Optic nerve disorder Branch retinal vein occlusion Sclerosed retinal vessels Iris atrophy with posterior synechiae Transient OA narrowing | Allergic skin reaction Forehead skin pigmentation Pancytopenia Leukopenia Thrombocytopenia Eosinophilia lymphocytopenia | 0 | 0 | |||||||||||||||||||
| Canan Akyüz et al. (2015) | 56 | NA | M | Primary (12) secondary (44) | 66% | Secondary 64% | Eyelid edema Conjunctival chemosis Upper eyelid chemosis Redness over frontal area Limitation in ocular motility Mild proptosis Retinal pigment epithelium alteration Optic atrophy | 0 | NA | 2 | |||||||||||||||||||
| Pukhraj Rishi et al. (2017) | 10 | NA | M, T + VEC + TTT + IVitC + Cryo | Primary (2) Secondary (8) | 80% | Group D 45% - 94% | Ophthalmic artery narrowing Branch retinal vein occlusion Sclerosed vessels Posterior subcapsular cataract Forehead skin Pigmentation Vitreous hemorrhage | Pancytopenia Leukopenia Thrombocytopenia |
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| Carol Shields et al. (2011) | 17 | 16 | M, C | NA | NA | NA | Eyelid edema Blepharoptosis Cilia loss Orbital congestion Dysmotility Ophthalmic artery stenosis Central or branch Retinal artery occlusion Retinal pigment epithelial mottling Choroidal atrophy Eyelashes loss Neovascularization of the iris Neovascular glaucoma | Cytopenia Internal carotid artery spasm | 0 | NA | |||||||||||||||||||
| Rojanaporn et al. (2019) | 27 | 75 (94%) | M, C, T | Primary (7) Secondary (20) | 52% | Group B, C (100%), Group D (75%), Group E (9%) | Occlusive vasculopathy Vitreous hemorrhage Retinal artery precipitation Strabismus | Transient ischemic attack | 1 | 1 | |||||||||||||||||||
| Pukhraj Rishi, et al. (2015) | 6 | NA | M, T | Primary (1) Secondary (5) | 83% | NA | Diffuse choroidal atrophy Vitreous hemorrhage | 0 | 0 | NA | |||||||||||||||||||
| Hutchinson, et al. (2012) | 1 | 1 | M | Primary | 100% | Group D | NA | NA | 0 | 0 | |||||||||||||||||||
| Pierre Gobin, et al. (2011) | 95 | 255/259 (98.5%) | M, T, C, Mtx. | Primary (39) Secondary (56) | 70% | 81.7% primary 58.4% secondary Group V 66.5%. | Temporary inflammatory syndrome with redness and periocular edema Avascular retinopathy with total vision loss Cataract Temporary loss of eyelashes. Transient skin redness. | Neutropenia Fever Bronchospasm | 2 | 0 | |||||||||||||||||||
| Santiago Funes et al. (2018) | 97 | NA (99%) | M, C, T | Primary (35) Secondary (62) | 65% | NA | Eyelid edema Focal alopecia Localized forehead erythema 3rd cranial nerve palsy Retinal and choroidal vascular occlusion Vision loss Ptosis | Hematopoietic toxicity Bronchospasm Femoral artery thrombosis | 0 | 0 | |||||||||||||||||||
| Khaqan et al. (2020) | 3 | NA | M | Primary | 100% | 100% in stage C 100% in stage D | Lid edema Skin hyperemia Orbital congestion | None. | NA | NA | |||||||||||||||||||
| Qiuying Chen et al. (2020) | 231 | NA | IAC: M, C, T IVC: C, E, V, Tn | NA | NA | IVC + IAC: D 71.7% E 33.3%. IAC alone: D 80%. E 32%. | NA | NA | Present but no set numbers | 9 | |||||||||||||||||||
| Evan B Selzer, et al. (2019) [27] | 13 | NA | M, C, T. | Primary (8). Secondary (5). | 62% | NA | NA | NA | 0 | 0 | |||||||||||||||||||
| Samuray Tuncer, et al. (2016) | 26 | 74/76 (97.3%) | M, C, T. | Primary | 66.6% | NA | Retinal detachment. Localized chorioretinal atrophy. Diffuse chorioretinal atrophy. Vitreous hemorrhage. Ptosis. Eyelid edema. hyperpigmentation on the forehead. | Nausea and vomiting. Anaphylactoid reaction. | 0 | 0 | |||||||||||||||||||
| Miaojuan Chen et al. (2016) | 13 | 27/28 (96%) | M, C, T | Primary | NA | NA | Ptosis Vitreous hemorrhage Phthisis Eyelid edema Choroidal infarction | Neutropenia | 0 | 0 | |||||||||||||||||||
| David H. Abramson, et al. (2016) | 120 | NA | M, T, C, Mtx. | Primary (60) secondary (60) | 96.7% | ICRb: A-D 100% E 90% | NA | Fever Neutropenia | 0 | 1 | |||||||||||||||||||
| David H. Abramson, et al. (2012) | 49 | All except 1 | NA | NA | 100% | NA | NA | Hematological toxicity Febrile neutropenia. | 0 | 0 | |||||||||||||||||||