Group | Description | Prognosis |
A | Small tumors located away from the foveola or optic disc. Tumor ≤ 3 mm in basal dimension or thickness. | Very low risk |
B | Retinal tumors of any size or location not in group A without vitreous or subretinal seeding. Tumor < 3 mm in basal dimension or thickness or any of the following: 1) Macular location ≤ 3 mm to foveola; 2) Juxtapupillary location ≤ 1.5 mm to disc; 3) Clear subretinal fluid ≤ 3 mm from margin. | Low risk |
C | Retinal tumors of any size and location with focal vitreous or subretinal seeding. One of the following: 1) Subretinal seeds ≤ 3 mm from tumor; 2) Vitreous seeds ≤ 3 mm from tumor; 3) Both subretinal and Vitreous seeds ≤ 3 mm from tumor; 4) Less than one quadrant of subretinal fluid in the fundus. | Moderate risk |
D | Massive tumor and/or diffuse vitreous or subretinal seeding One of the following: 1) Subretinal seeds > 3 mm from tumor; 2) Vitreous seeds > 3 mm from tumor; 3) Both subretinal and vitreous seeds > 3 mm from tumor; 4) Greater than one quadrant of subretinal fluid in the fundus. | High risk |
E | Tumor has destroyed the eye anatomically or functionally Extensive retinoblastoma or one of the following: 1) Irreversible neovascular glaucoma; 2) Massive intraocular hemorrhage; 3) Invasion of post laminar optic nerve, choroid (>2 mm), sclera, orbit, anterior chamber; 4) Tumor anterior to the anterior vitreous face; 5) Diffuse infiltrating tumor; 6) Phthisis bulbi or pre phthisis; 7) Aseptic orbital cellulitis. | Very unfavorable |