Organ/Tissue | T1 Control | T2 100 mg/kg Sangrovit® | T3 500 mg/kg Sangrovit® | T4 1000 mg/kg Sangrovit® | Treatment effect P= | ||||
F | CM | F | CM | F | CM | F | CM | ||
Skin | 0.50 ± 0.58 | 1.00 ± 0.00 | 0.50 ± 0.58 | 0.50 ± 0.58 | 0.50 ± 0.58 | 0.75 ± 0.50 | 0.25 ± 0.50 | 1.00 ± 0.00 | 0.8095 |
Brain | 0.00 ± 0.00 | 0.25 ± 0.50 | 0.25 ± 0.50 | 0.00 ± 0.00 | 0.25 ± 0.50 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.25 ± 0.50 | 1.0000 |
Eyes | 0.00 ± 0.00 | 0.25 ± 0.50 | 0.75 ± 0.96 | 0.25 ± 0.50 | 0.50 ± 0.58 | 0.50 ± 0.58 | 0.50 ± 0.58 | 0.25 ± 0.50 | 0.5044 |
Pituitary gland | 0.50 ± 0.58 | 0.00 ± 0.00 | 0.25 ± 0.50 | 0.25 ± 0.50 | 0.00 ± 0.00 | 0.25 ± 0.50 | 0.25 ± 0.50 | 0.00 ± 0.00 | 0.8637 |
Thyroid gland | 0.25 ± 0.50 | 0.25 ± 0.50 | 0.00 ± 0.00 | 0.50 ± 0.58 | 0.00 ± 0.00 | 0.50 ± 0.58 | 0.25 ± 0.50 | 0.50 ± 0.58 | 0.9369 |
Parathyroid gland | 0.50 ± 0.58 | 0.25 ± 0.50 | 0.25 ± 0.50 | 0.00 ± 0.00 | 0.25 ± 0.50 | 0.00 ± 0.00 | 0.25 ± 0.50 | 0.00 ± 0.00 | 0.5163 |
Heart | 0.25 ± 0.50 | 0.00 ± 0.00 | 0.25 ± 0.50 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.50 ± 0.58 | 0.5496 |
Lung | 0.50 ± 0.58 | 0.75 ± 0.96 | 0.75 ± 0.96 | 0.50 ± 0.58 | 0.50 ± 0.58 | 0.25 ± 0.50 | 0.50 ± 0.58 | 0.50 ± 0.58 | 0.8013 |
Spinal cord | 0.25 ± 0.50 | 0.25 ± 0.50 | 0.50 ± 0.58 | 0.25 ± 0.50 | 0.50 ± 0.58 | 0.00 ± 0.00 | 0.25 ± 0.50 | 0.25 ± 0.50 | 0.9369 |
Stomach | 0.25 ± 0.50 | 0.50 ± 0.58 | 0.50 ± 0.58 | 0.00 ± 0.00 | 0.25 ± 0.50 | 0.25 ± 0.50 | 0.25 ± 0.50 | 0.25 ± 0.50 | 0.9369 |
Liver | 0.75 ± 0.96 | 0.50 ± 0.58 | 0.25 ± 0.50 | 1.00 ± 0.00 | 0.50 ± 0.58 | 0.50 ± 0.58 | 0.75 ± 0.96 | 0.50 ± 0.58 | 0.9507 |
Gall bladder | 0.25 ± 0.50 | 0.50 ± 0.58 | 0.50 ± 0.58 | 0.50 ± 0.58 | 0.25 ± 0.50 | 0.25 ± 0.50 | 0.25 ± 0.50 | 0.25 ± 0.50 | 0.7079 |
Lymph nodes | 0.50 ± 0.58 | 0.00 ± 0.00 | 0.25 ± 0.50 | 0.25 ± 0.50 | 0.50 ± 0.58 | 0.25 ± 0.50 | 0.00 ± 0.00 | 0.50 ± 0.58 | 0.9369 |
Spleen | 0.00 ± 0.00 | 0.25 ± 0.50 | 0.50 ± 0.58 | 0.75 ± 0.96 | 0.25 ± 0.50 | 0.50 ± 0.58 | 0.50 ± 0.58 | 0.25 ± 0.50 | 0.3664 |
Pancreas | 0.00 ± 0.00 | 0.25 ± 0.50 | 0.25 ± 0.50 | 0.50 ± 0.58 | 0.00 ± 0.00 | 0.25 ± 0.50 | 0.25 ± 0.50 | 0.25 ± 0.50 | 0.9369 |
Kidneys | 0.00 ± 0.00 | 0.50 ± 0.58 | 0.50 ± 0.58 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.4376 |
Adrenal gland | 0.25 ± 0.50 | 0.25 ± 0.50 | 0.50 ± 0.58 | 0.00 ± 0.00 | 0.25 ± 0.50 | 0.25 ± 0.50 | 0.00 ± 0.00 | 0.75 ± 0.96 | 0.9369 |
Bone and marrow | 0.25 ± 0.50 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.25 ± 0.50 | 0.00 ± 0.00 | 0.50 ± 0.58 | 0.00 ± 0.00 | 0.25 ± 0.50 | 0.8871 |
Marrow smear | 0.50 ± 0.58 | 0.25 ± 0.50 | 0.25 ± 0.50 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.25 ± 0.50 | 0.00 ± 0.00 | 0.2288 |
Duodenum | 0.25 ± 0.50 | 0.50 ± 0.58 | 0.50 ± 0.58 | 0.00 ± 0.00 | 0.25 ± 0.50 | 0.25 ± 0.50 | 0.25 ± 0.50 | 0.25 ± 0.50 | 0.3664 |
Jejunum | 0.50 ± 0.58 | 0.25 ± 0.50 | 0.25 ± 0.50 | 0.50 ± 0.58 | 0.25 ± 0.50 | 0.25 ± 0.50 | 0.75 ± 0.96 | 0.00 ± 0.00 | 0.9459 |
Ileum | 0.50 ± 0.58 | 0.75 ± 0.96 | 0.75 ± 0.96 | 0.25 ± 0.50 | 0.50 ± 0.58 | 0.25 ± 0.50 | 0.25 ± 0.50 | 0.50 ± 0.58 | 0.7395 |
Colon | 0.00 ± 0.00 | 0.25 ± 0.50 | 0.00 ± 0.00 | 0.25 ± 0.50 | 0.00 ± 0.00 | 0.25 ± 0.50 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.8013 |
Caecum | 0.00 ± 0.00 | 0.25 ± 0.50 | 0.50 ± 0.58 | 0.75 ± 0.96 | 0.25 ± 0.50 | 0.50 ± 0.58 | 0.50 ± 0.58 | 0.25 ± 0.50 | 0.9459 |
Thymus | 0.25 ± 0.50 | 0.25 ± 0.50 | 0.75 ± 0.96 | 0.25 ± 0.50 | 0.75 ± 0.96 | 0.25 ± 0.50 | 0.00 ± 0.00 | 0.50 ± 0.58 | 0.5796 |
Muscle | 0.75 ± 0.96 | 0.75 ± 0.96 | 0.50 ± 0.58 | 0.50 ± 0.58 | 1.00 ± 0.00 | 0.75 ± 0.96 | 0.50 ± 0.58 | 0.75 ± 0.96 | 0.4376 |
Urinary bladder | 0.00 ± 0.00 | 0.50 ± 0.58 | 0.25 ± 0.50 | 0.25 ± 0.50 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.25 ± 0.50 | 0.00 ± 0.00 | 0.6549 |
Ovaries | 0.75 ± 0.96 | -1 | 0.25 ± 0.50 | - | 0.75 ± 0.96 | - | 0.75 ± 0.96 | - | 0.4262 |
Uterus | 0.50 ± 0.58 | - | 0.50 ± 0.58 | - | 0.50 ± 0.58 | - | 0.75 ± 0.96 | - | 0.8944 |
Mammary gland | 0.50 ± 0.58 | 0.00 ± 0.00 | 0.25 ± 0.50 | 0.25 ± 0.50 | 0.00 ± 0.00 | 0.25 ± 0.50 | 0.25 ± 0.50 | 0.00 ± 0.00 | 0.6695 |