Variable (Average/Mean ± SD)

baseline

The 1^st course

The 2^nd course

The 3^rd course

P value

Times to A & E

0.51 ± 1.23

0.18 ± 0.53

1.24 ± 10.38

0.07 ± 0.25

0.339

Times to hospital

1.41 ± 10.40

0.11 ± 0.41

0.09 ± 0.49

0.04 ± 0.21

0.227

Times to clinic

18.88 ± 48.40

4.15 ± 12.20

5.03 ± 15.09

0.57 ± 0.52

0.002^##

Times to persistent

130.03 ± 93.35

47.63 ± 103.01

64.08 ± 175.21

16.86 ± 93.95

0.001^##

Times by own medicine

20.57 ± 39.46

4.63 ± 20.37

2.40 ± 14.59

1.42 ± 10.48

0.000^###

Times of not proceed

9.84 ± 43.96

14.60 ± 115.44

3.31 ± 19.46

1.29 ± 10.38

0.386