| Baseline & The 1st course | Baseline & The 2nd course | Baseline & The 3rd course | The 1st course & The 2nd course | The 1st course & The 3rd course | The 2nd course & The 3rd course | |
| −2.714b | −4.796b | −3.838b | −3.130b | −1.732b | −1.091c | Z value |
| 0.007## | 0.000### | 0.000### | 0.002## | 0.083 | 0.275 | P value |