| Category | Mode |
| Amino acid composition | 1) Distance-based Residue (DR) [ 271 ] |
| 2) PseAAC of Distance-Pairs and Reduced Alphabet (Distance Pair) [ 271 ] | |
| Autocorrelation | 3) Physicochemical distance transformation (PDT) [ 270 ] |
| Profile-based features | 4) Select and combine the n most frequenct amino acids according to their frequencies (Top-n-gram) [ 269 ] |
| 5) Profile-based Physicochemical distance transformation (PDT-Pofile) [ 270 ] | |
| 6) Distance-based Top-n-gram (DT) [ 271 ] | |
| 7) Profile-based Auto covariance (AC-PSSM) [ 272 ] | |
| 8) Profile-based Cross covariance (CC-PSSM) [ 272 ] | |
| 9) Profile-based Auto-cross covariance (ACC-PSSM) [ 272 ] |