Outcomes and Comments

1) Bäckhed et al. (2004) [13]

Rats with sterile microbiota and conventional mice.

Time period: 2 weeks

Evaluate the colonization and change of intestinal microflora of mice

It showed that the microbiota transported from obese rats to the sterile mice not only increased the absorption of calories from the diet, but also increased the adiposity in these rats, even maintaining the standard diet.

2) Turnbaugh et al. (2006) [17]

Obese rats (ob:ob) and lean mice

Analyze the relationship between obesity and intestinal microbiota

Microbiota of obese ≥ ability to store energy

3) Collado et al. (2008) [21]

18 pregnant women with overweight and 36 with normal weight. Follow up for 9 months.

To evaluate the composition of the intestinal microbiota

Microbiota of overweight women ≥ concentration of Bacterioides and Staphylococcus

The greater the overweight > the concentration of Bacteroidetes, Clostridium and Staphylococcus

4) Ley et al. (2005) [14]

Genetically obese mice (ob/ob) and lean mice monitoring for 2 weeks

To compare the intestinal microbiota of ob/ob versus lean mice

Obesity rats colonized with microbiota had modest fat gain and extracted more energy from their diet.

5) Kalliomäki et al. (2008) [18]

25 obese and overweight children 24 with normal weight Ages between 4 and 7 years

To establish whether the composition of the early intestinal microbiota may influence body weight in childhood

Microbiota of obese and overweight ≥ concentration of Staphylococcus aureus Microbiota of children with normal weight ≥ number of Bifidobacteria

6) Santa Cruz et al. (2010) [19]

Intestinal Microbiotic Analysis of pregnant women (50) obese (16) and non-obese (34)

To analyze the composition of the intestinal microbiota of healthy and obese pregnant women, to establish the relationship between the microbiota and weight gain during pregnancy

Microbiota of obese pregnant women is different from the microbiota of previously healthy pregnant women

7) Jumpertz et al. [20]

Evaluation of the role of the microbiota in the regulation of nutrient absorption in twelve lean and nine obese individuals subject to a daily diet of different energy value

Evaluation of the regulation of nutrient bioavailability

The change in nutrient load-induced microbiota is directly related to feces in lean individuals and that a 20% increase in Firmicutes and a corresponding decrease in Bacteroidetes was associated with an increased energy absorption of 150 kcal