Year	Authors	Authors’ contributions
1978	Arber, Nathans and Smith	Discovery of restriction enzymes and their application to problems of molecular genetics. Nobel Prize in Physiology or Medicine 1978
1978	Szybalski and Skalka	Work on restriction nucleases, which led us to new synthetic biology, allowing the description and analysis not only of existing genes, but also of new genetic arrangements.
1995	J. Craig Venter et al.	Beginning of sequence analysis of Mycoplasma genitalium
2005	Endy	Ability to quickly and reliably design biological systems that behave as expected remains limited.
2007	J. Craig Venter et al.	Deciphering of the chromosome transplant stage. The turning of one species of bacteria into another.
2010	J. Craig Venter et al.	Creation of the first living organism controlled by a synthetic genome, that is, the bacterium Mycoplasma mycoides JCVI-syn1.0.
2010	Bar-Even, et al. [1]	Use of synthetic organisms for improvements in the carbon sequestration process. Higher speed and effectiveness in the process compared to the process performed with natural organisms.
2013	You et al. [9]	Creation of a production model based on a trilema: food, biofuel and environment, through the enzymatic conversion of unnatural synthetic biomass. It aims to increase production, minimizing the environmental footprint of agriculture, conserving biodiversity.
2015-2016	Ort et al. [10] Yang et al. [11] Hoffman [12]	Use of synthetic organisms for engineering of photosynthesis aimed to: increase crop productivity; increase efficiency in water use; biomass on semi-arid, abandoned, marginal or degraded agricultural land; application in bioenergy, food and feed; environmental remediation; and conservation of land, soil and water.
2016	Li et al. [15]	Experimental study analyzing 4-hydroxymandelic acid (4-HMA), presenting a production approach from renewable and sustainable resources, reducing the impact caused in the environment.
2016	Bills and Gloer [13] ; Sivasubramaniam and Franks [14]	Analysis of the metabolism of fungi and microbial organisms. They emphasize the potential of the technologies, yet point out the need for studies on food safety, public perceptions and expectations of individuals regarding such technology.
2017	Heavey [16] Frewer [18]	Analysis of the consequences of such technologies: ethics; food safety; perceptions of risk and consumer benefits; acceptance or rejection of emerging agro-food technologies.
2018	Grewal et al. [19] Lokko et al. [20]	Resumption of experimental studies of new technologies, as well as the approach of the bioeconomics theme, bringing the topic of synthetic biology into the sustainable industrial area.