Before (Lines published in 2014) | After (Lines published in 2018) |
1st line treatment regimens | 1st line treatment regimens |
Main regimen: TDF+ FTC (or FTC) + EFV in fixed-dose combinations Alternative: - TDF + 3TC (or FTC) + NVP - AZT + 3TC + NVP (or EFV) - ABC + 3TC + NVP (or EFV) - AZT (or ABC) + 3TC + LPVr (or ATVr) | Main regimen: TDF+3TC (or FTC) +EFV Alternative: - TDF + 3TC + DTG - AZT + 3TC + EFV - ABC + 3TC + DTG - AZT + 3TC + NVP |
2nd line treatment regimens | 2nd line treatment regimens |
If 1st line Protocol with TDF give in 2nd line this: AZT + 3TC + LPV/r (1st intention) AZT + 3TC + ATV/r (2nd intention) If 1st line Protocol with AZT, give in 2nd line this: TDF + 3TC (ou FTC) + LPV/r TDF + 3TC (ou FTC) + ATV/r | - If 1st line received is: TDF + 3TC (or FTC) +EFV, the 2nd line will be: AZT + 3TC + LPV/R - If 1st line received is: TDF + 3TC + DTG, the 2nd line will be: AZT + 3TC + EFV |
3rd line treatment regimens | 3rd line treatment regimens |
Darunavir (DRV) + Etravirine (ETV) + Raltegravir (RAL) | The 3rd line treatment must be initiated according to the genotyping results. In the absence of genotyping: - 2 INRT + RAL (or DTG or DRV + RTV) - DRV + RTV + RAL or DTG± 1 or 2 INRT |