| strains | 2005-2006 season | 2006-2007 season | 2007-2008 season | 2008-2009 season | 2009-2010 season | ||||||
| before (95% CI) | 4 weeks after vacc. (95% CI) | before (95% CI) | 4 weeks after vacc. (95% CI) | before (95% CI) | 4 weeks after vacc. (95% CI) | before (95% CI) | 4 weeks after vacc. (95% CI) | before (95% CI) | 4 weeks after vacc. (95% CI) | ||
| H1N1 | nonresponder (n = 25) | 0.00 (0.00 - 0.00) | 0.00 (0.00 - 0.00) | 0.00 (0.00 - 0.00) | 12.0 (−0.74 - 24.7) | 0.00 (0.00 - 0.00) | 36.0 (17.2 - 54.8) | 16.0 (1.67 - 30.4) | 36.0 (17.2 - 54.8) | 8.00 (−2.63 - 18.6) | 28.0 (10.4 - 45.6) |
| responder (n = 86) | 43.0 (32.5 - 53.5) | 100.0 (100.0 - 100.0) | 33.7 (23.7 - 43.7) | 57.0 (46.5 - 67.5) | 8.14 (2.36 - 13.9) | 67.4 (57.5 - 77.3) | 31.4 (21.6 - 41.2) | 53.5 (43.0 - 64.0) | 23.3 (14.4 - 32.2) | 51.2 (40.6 - 61.8) | |
| p-value | 0.000 | - | 0.000 | 0.000 | 0.346 | 0.010 | 0.204 | 0.173 | 0.152 | 0.067 | |
| H3N2 | nonresponder (n = 24) | 0.00 (0.00 - 0.00) | 0.00 (0.00 - 0.00) | 0.00 (0.00 - 0.00) | 29.2 (11.0 - 47.4) | 12.5 (−0.73 - 25.7) | 41.7 (22.0 - 61.4) | 0.00 (0.00 - 0.00) | 37.5 (18.1 - 56.9) | 4.17 (−3.83 - 12.2) | 37.5 (18.1 - 56.9) |
| responder (n = 87) | 40.2 (29.9 - 50.5) | 100.0 (100.0 - 100.0) | 33.3 (23.4 - 43.2) | 64.4 (54.3 - 74.5) | 55.2 (44.8 - 65.6) | 82.8 (74.9 - 90.7) | 21.8 (13.1 - 30.5) | 66.7 (56.8 - 76.6) | 37.9 (27.7 - 48.1) | 70.1 (60.5 - 79.7) | |
| p-value | 0.000 | - | 0.000 | 0.003 | 0.000 | 0.000 | 0.011 | 0.017 | 0.001 | 0.008 | |
| B | nonresponder (n = 24) | 0.00 (0.00 - 0.00) | 0.00 (0.00 - 0.00) | 1.72 (−3.48 - 6.92) | 10.3 (−1.86 - 22.5) | 3.45 (−3.85 - 10.8) | 10.3 (−1.86 - 22.5) | 0.00 (0.00 - 0.00) | 6.90 (−3.24 - 17.0) | 8.62 (−2.61 - 19.8) | 17.2 (2.10 - 32.3) |
| responder (n = 87) | 43.4 (33.0 - 53.8) | 100.0 (100.0 - 100.0) | 18.9 (10.7 - 27.1) | 32.1 (22.3 - 41.9) | 24.5 (15.5 - 33.5) | 41.5 (31.1 - 51.9) | 32.1 (22.3 - 41.9) | 52.8 (42.3 - 63.3) | 26.4 (17.1 - 35.7) | 58.5 (48.1 - 68.9) | |
| p-value | 0.000 | - | 0.003 | 0.009 | 0.002 | 0.000 | 0.011 | 0.000 | 0.022 | 0.000 | |