Group

Sheep

Viremia (log10 BTV copies/2 μg blood RNA)

0 dpi

2 dpi

4 dpi

6 dpi

8 dpi

10 dpi

12 dpi

14 dpi

16 dpi

1 μg/dose

1 - 6

NVDa

NVD

NVD

NVD

NVD

NVD

NVD

NVD

NVD

5 μg/dose

7

NVD

NVD

NVD

NVD

NVD

NVD

NVD

NVD

NVD

8

NVD

NVD

NVD

NVD

NVD

NVD

NVD

NVD

NVD

9

NVD

NVD

NVD

NVD

NVD

NVD

NVD

NVD

NVD

10

NVD

NVD

NVD

NVD

NVD

NVD

NVD

NVD

NVD

11

NVD

NVD

3.01

5.12

5.12

4.21

4.82

4.52

4.21

12

NVD

NVD

NVD

NVD

NVD

NVD

NVD

NVD

NVD

10 μg/dose

13 - 18

NVD

NVD

NVD

NVD

NVD

NVD

NVD

NVD

NVD

50 μg/dose

19 - 24

NVD

NVD

NVD

NVD

NVD

NVD

NVD

NVD

NVD

Naive control

25

NVD

NVD

5.42

5.42

5.42

5.12

4.52

4.21

4.52

26

NVD

NVD

3.91

5.42

5.12

5.12

4.82

4.82

4.82

27

NVD

NVD

NVD

5.72

4.82

5.12

4.82

4.82

4.82

28

NVD

NVD

3.91

5.42

5.42

5.12

4.52

5.12

4.82

29

NVD

NVD

5.72

4.52

4.21

5.12

4.52

4.82

4.82

30

NVD

NVD

5.12

4.21

4.52

3.61

4.21

3.91

4.21