Variable

Baseline

12 months

24 months

36 months

48 months

One-way ANOVA; p-value

p-trend

FSH (IU/L)

Observed group

23.30

±

8.642

24.91

±

8.446****

25.52

±

8.339**

26.31

±

8.257**

27.03

±

8.799***

F (4,125) = 0.7348; p = 0.5699

0.0949

Surgery group

24.28

±

7.001

20.69

±

6.947****

16.59

±

5.197****

15.57

±

4.512****

13.87

±

4.019****

F (4,130) = 14.99; p < 0.0001

<0.0001

p-value

0.6522

0.0518

<0.0001

<0.0001

<0.0001

LH (IU/L)

Observed group

11.21

±

3.168

12.00

±

3.335****

13.07

±

3.850****

13.91

±

4.368****

14.94

±

4.439****

F (4,125) = 3.823; p = 0.0058

0.0002

Surgery group

12.46

±

4.207

9.419

±

2.410****

7.970

±

1.668****

7.752

±

1.313****

7.323

±

1.452****

F (4,130) = 19.80; p < 0.0001

<0.0001

p-value

0.2281

0.0021

<0.0001

<0.0001

<0.0001

Testosterone (nmol/L)

Observed group

2.069

±

0.899

1.931

±

1.931**

1.977

±

0.9052

1.773

±

0.8488***

1.869

±

1.333

F (4,125) = 0.3298; p = 0.8575

0.3654

Surgery group

2.185

±

0.730

3.644

±

1.239****

5.915

±

2.101****

6.444

±

2.211****

6.667

±

2.202****

F (4,130) = 32.17; p < 0.0001

<0.0001

p-value

0.6078

<0.0001

<0.0001

<0.0001

<0.0001