Genetic variants associated with T2D or glycemic traits

Localization

Locus name

Chromosome

associated SNP

established loci

Literature

non- and endodermal

TCF7L2

10

rs4506565, rs7903146, rs12243326

T2DM

Dupuis et al., 2012; Saxena et al., 2010

endodermal

KCNQ1

11

rs2237892, rs231362

T2DM

Yasuda et al., 2008; Voight et al., 2010

endodermal

PROX1

1

rs340874

T2DM

Dupuis et al., 2012

endodermal

HNF1β

17

rs757210, rs4430796, rs7501939

T2DM

Pearson et al., 2007; Winckler et al., 2007; Wang et al., 2014

endodermal

KCNJ11

11

rs5219, rs757110

T2DM

Gloyn et al., 2003

endodermal

GCK

7

rs1799881, rs6975024, rs4607517, rs3757840

T2DM

Dupuis et al., 2012; Soranzo et al., 2010; Scott et al., 2012

endodermal

FOXA2

20

rs6113722, rs6048205

T2DM

Scott et al., 2012; Manning et al., 2012

endodermal

PDX1

13

rs11619319, rs2293941

T2DM

Scott et al., 2012; Manning et al., 2012