Study Design | Regimen | Study duration (Days) | No. of patients |
| Before treatment | After treatment |
Add-on Therapy (Tene + Insulin) [25] | Tene 20 mg + Daily insulin dose of ≤60 units | 7 | 26 | Mean glucose level (mg/dL) 0:00 - 7:00 h 7:00 - 24:00 h | 148.8 ± 25.7 126.0 ± 7.5 159.1 ± 9.8 | 131.3 ± 17.0b 119.0 ± 4.2b 138.0 ± 9.1b |
SD over 24 h (mg/dL) | 32.0 ± 16.2 | 26.9 ± 10.9b | ||||
MAGE (mg/dL) | 90.1 ± 46.7 | 85.5 ± 34.3a | ||||
Proportion (%) of time in Hypoglycemia (<70 mg/dL) Hyperglycemia ( >140 mg/dL) |
1.0 ± 2.4
59.8 ± 24.7 |
1.6 ± 2.6
37.6 ± 22.4b |