Study Design

Regimen

Study duration (Days)

No. of patients

Before treatment

After treatment

Add-on

Therapy

(Tene + Insulin) [25]

Tene 20 mg +

Daily insulin dose of ≤60 units

7

26

Mean glucose level (mg/dL)

0:00 - 7:00 h

7:00 - 24:00 h

148.8 ± 25.7

126.0 ± 7.5

159.1 ± 9.8

131.3 ± 17.0b

119.0 ± 4.2b

138.0 ± 9.1b

SD over 24 h (mg/dL)

32.0 ± 16.2

26.9 ± 10.9b

MAGE (mg/dL)

90.1 ± 46.7

85.5 ± 34.3a

Proportion (%) of time in

Hypoglycemia

(<70 mg/dL)

Hyperglycemia

( >140 mg/dL)

1.0 ± 2.4

59.8 ± 24.7

1.6 ± 2.6

37.6 ± 22.4b