Rosuvastatin 1.2 mg in Situ Gel Combined it 1:1 Mixture of autologous platelet-rich fibrin and porus-hydroxyappatite bone graft in surgical treatment of mandibular degree ii furcation defects: a randomized clinical control trial | Clinical Trial | Pradeep, A. R., Karvekar, S., Nagpal, K. | 2016 | India | Rosuvastatin | Positive |
Rosuvastatin Regulates Odontoblast Differentiation by Suppressing NF-jB Activation in an Inflammatory Environment | Pre-Clinical Trial | Feng, X., Wang, C., Gu, Z. | 2019 | China | Rosuvastatin | Positive |
Diagnosis of osteoporosis in statin-treated patients is dose-dependent | Clinical Trial | 1) Leutner, M., 2) Matzhold, C., 3) Bellach, L. | 2019 | Austria | Lovastatin, Sinvastatin, Pravastatin and Rosuvastatin | Dosis-dependent could be positive or not |
Atorvastatin promotes bone formation in aged apoE–/– mice through the Sirt1–Runx2 axis | Pre-Clinical Trial | Hong, W., Wei, Z., Qiu, Z. | 2020 | China | Atorvastatin | Positive |
Comparison the effects of chitosan and hyaluronic acid-based thermally sensitive hydrogels containing rosuvastatin on human osteoblast-like MG-63 cells | Pre-Clinical Trial In-vitro | Akbari, V., Rezazadeh, M., & Ebrahimi, Z. | 2020 | Iran | Rosuvastatin | Positive |
Evaluation of the effects of locally applied rosuvastatin on bone formation in a three dimensional reconstruction rabbit xenograft model | Pre-Clinical Trial | Özer, T., Aktaş, A., Avağ, C. | 2021 | Turkey | Rosuvastatin | Positive |
Peri-implant marginal bone loss and systemic statin use: A retrospective cohort pilot study | Clinical Trial | Bahrami-Hessari, B., & Jansson, L. | 2022 | Sweden |
| Negative |
Comparative evaluation of autogenous bone graft and autologous platelet—Rich fibrin with and without 1.2 mg in situ rosuvastatin gel in the surgical treatment of intrabony defect in chronic periodontitis patients | Clinical Trial | Gautam, K., Kapoor, A., Mathur, S. | 2022 | India | Rosuvastatin | Positive |