Work title | Type of study | Authors | Year | Place | Drug | Effect |
Effect of pravastatin on frequency of fracture in the LIPID study: secondary analysis of a randomised controlled trial | Clinical Trial | Reid, I. R., Hague, W., Emberson, J. | 2001 | New Zealand | Pravastatin | Neutral |
Statin given perorally to adult rats increases cancellous bone mass and compressive strength | Pre-Clinical Trial | IN., Dalstra, M., Andreassen, T. T. | 2001 | Denmark | Simvastatin | Positive |
The effect of atorvastatin on markers of bone turnover in patients with type 2 diabetes | Clinical Trial | Braatvedt, G. D., Bagg, W., Gamble, G. | 2004 | New Zealand | Atorvastatin | Neutral |
Simvastatin treatment partially prevents ovariectomy-induced bone loss while increasing cortical bone formation | Pre-Clinical Trial | Oxlund, H., & Andreassen, T. T | 2004 | Denmark | Simvastatin | Positive |
Effects of Atorvastatin on Bone in Postmenopausal Women with Dyslipidemia: A Double-Blind, Placebo-Controlled, Dose-Ranging Trial | Clinical Trial | Bone, H. G., Kiel, D. P., Lindsay, R. S. | 2007 | EE.UU | Atorvastatin | Neutral |
A Comparison between the Effects of Hydrophobic and Hydrophilic Statins on Osteoclast Function In Vitro and Ovariectomy-Induced Bone Loss In Vivo | Pre-Clinical Trial | Hughes, A., Rogers, M. J., Idris, A. I. | 2007 | U.K | Rosuvastatin, Pravastatin, Cerivastatin and Sinvastatin | Neutral |
Statins attenuate polymethylmethacrylate-mediated monocyte activation | Pre-Clinical Trial In-vitro | Laing, A. J., Dillon, J. P., Mulhall, K. J. | 2008 | Ireland | Cerivastatin | Positive |
Effects of statins vs. non-statin lipid-lowering therapy on bone formation and bone mineral density biomarkers in patients with hiperlipidemia | Clinical Trial | Chuengsamarn, S., Rattanamongkoulgul, S., Suwanwalaikorn, S. | 2010 | Thailand | Simvastatin, Gemfibrozil | Positive |
Simvastatin promotes osteoblast viability and differentiation via Ras/Smad/Erk/BMP-2 signaling pathway | Pre-Clinical Trial | Chen, P. Y., Sun, J. S., Tsuang, Y. H. | 2010 | Taiwan | Simvastatin | Positive |