Function

Acute Wound

Chronic Wound

EGF (PI, Ma, F)

epithelialization

↑

↓

FGF-2 (K, MAS. F. CE, CML. C)

Granulation, epithelialization, extracellular matrix

↑

↓

TGF-β (PI, K, M, L, F)

↑

↓

PDGF (PI, K < Ma, CE, F)

↑

↓

VEGF

Granulation

↑

↓

IL-1 (N, M, Ma, K)

IL-6 (N, Ma)

TNF-α (N, Ma)

inflammation, epithelialization

↑

↑