Kinetic Model



Plot Graph


Zero order

C = C o + K o t

Where, C0 is the initial concentration of drug at time t = 0, K0 is zero order rate constant, t is the time taken for C amount of drug release

Cumulative % drug release vs. time

Okano et al., 1987

Yin et al., 2009

Park, 2014

First order

log C t = ( log C o k 1 t ) 2.303

Where, Ct is amount of drug released in t time and C0 is the initial amount of drug, K1 is first order rate constant

Log % of drug remaining vs. time and the slope of the plot gives the first order rate constant

Hallam et al., 1983

Shah and Rajput, 2017

Mucientes and Peña, 2009


Q = K H t 1 / 2

KH is Higuchi dissolution constant, Q is the amount of drug released in time t per unit area

Cumulative % drug release vs. square root of time

Gouda et al., 2017

Higuchi, 1963

Siepmann and Peppas, 2011