Kinetic Model | Equation | Description | Plot Graph | Ref. |
Zero order |
| Where, C0 is the initial concentration of drug at time t = 0, K0 is zero order rate constant, t is the time taken for C amount of drug release | Cumulative % drug release vs. time | Okano et al., 1987 Yin et al., 2009 Park, 2014 |
First order |
| Where, Ct is amount of drug released in t time and C0 is the initial amount of drug, K1 is first order rate constant | Log % of drug remaining vs. time and the slope of the plot gives the first order rate constant | Hallam et al., 1983 Shah and Rajput, 2017 Mucientes and Peña, 2009 |
Higuchi |
| KH is Higuchi dissolution constant, Q is the amount of drug released in time t per unit area | Cumulative % drug release vs. square root of time | Gouda et al., 2017 Higuchi, 1963 Siepmann and Peppas, 2011 |