| Performance test of WATERS HPLC equipment | ||||
| Pump | Nominal flow rate | |||
| Test of the accuracy of the programmed flow | 0.5 mL/min | 2 mL/min | 0.5 mL/min | 2 mL/min |
| Average deviation Dm (%) | 1.2 | 1.45 | 0.6 | 1.25 |
| European Pharmacopoeia Standard 8.2: Dm < 5% | Compliant | Compliant | Compliant | Compliant |
| Pump Repeatability Test (n = 6) | 0.5 mL/min | 2 mL/min | 0.5 mL/min | 2 mL/min |
| RSD (%) | 0.428 | 0.252 | ||
| European Pharmacopoeia Standard 8.2: RSD ≤ 0.5% | Compliant | Compliant | ||
| Injector | Propylparaben (PPB) peak area | |||
| Injector repeatability (n = 6) | 1660295.33 | |||
| RSD (%) | 0.72 | |||
| RSD limit (%) | 1 | |||
| European Pharmacopoeia Standard 8.2: RSD < RSD limit | Compliant | |||
| Linearity test of the injector volume (n = 5) | volume = f (PPB peak area) | |||
| Coefficient of determination (R2) | 0.9993 | |||
| European Pharmacopoeia Standard 8.2: R2 > 0.99 | Compliant | |||
| Detector | Peak area of caffeine | |||
| Linearity test of the detector (n = 5) | Volume = f (Caffeine peak area) | |||
| Coefficient of determination (R2) | 0.9994 | |||
| European Pharmacopoeia Standard 8.2: R2 > 0.99 | Compliant | |||