Parameter

Inclusion criteria

Exclusion criteria

Population

Female and male individuals over the age of 30 with a clinical diagnosis of PD consistent with the UK Brain Bank criteria who have a Hoehn and Yahr Stage 5 or less during OFF state

Individuals with a mini-mental state examination score of 24 or less

Intervention

MAO-B inhibitor Rasagiline

Other types of PD medication

Comparator

Placebo

No comparator

Outcome

UPDRS Part I, UPDRS Part II, UPDRS Part III, UPDRS Part IV and UPDRS total scores, PDQ-39 subdomain and total scores, and/or OFF time as efficacy endpoints

UPDRS Part I, UPDRS Part II, UPDRS Part III, UPDRS Part IV and UPDRS total scores, PDQ-39 subdomain and total scores, and/or OFF time not included as efficacy endpoints

Study design

Randomized Controlled Trials published in English

Expert opinions, editorials, case reports, abstracts without full reports, and preprints. Published in any other language than English