Non-improvement of wearing-off

Major PD symptoms

Postural abnormalities

Psychotic manifestations

Duration of PD (years)

8.5 ± 3.5

10.8 ± 7.8

7.5 ± 0.6

6.7 ± 3.5

Hoehn-Yahr stage

3.0 ± 0.8

3.0 ± 1.1

3.5 ± 0.6

3.7 ± 0.8

L-DOPA (mg/day)

575 ± 179

288 ± 116

500 ± 187

475 ± 194

Pramipexole (mg/day)

2.0 ± 0.8

2.3 ± 1.0

1.8 ± 0.4

1.8 ± 0.3

Ropinirole (mg/day

6.7 ± 3.5

3.7 ± 0.8

1.8 ± 0.4

1.8 ± 0.3