| n | Placebo |
| 20 mg |
| 40 mg | ||||||||||
| Mean age (SD) | Male % | Change of OFF time (hours) |
| Mean age (SD) | Male % | Change of OFF time (hours) | p-value |
| Mean age (SD) | Male % | Change of OFF time (hours) | p-value | |||
| LeWitt PA. et al. [12] | 2008 | 196 | 64 (10.0) | 60.6 | −0.64 |
| − | − | − | − |
| 63 (9.0) | 59.7 | −1.79 | 0.006 |
| Hauser RA. et al. [13] | 2008 | 231 | 64 (10.2) | 67.0 | −0.9 |
| 63 (9.5) | 66.1 | −1.6 | 0.03 |
| − | − | − | − |
| Pourcher E. et al. [14] | 2012 | 584 | 63 (8.3) | 64.2 | −1.3 |
| 64 (9.8) | 69.1 | −1.1 | − |
| 63 (9.3) | 65.8 | −1.5 | 0.529 (overall) |
| Mizuno Y. et al. [15] | 2010 | 363 | 65.0 (7.6) | 38.1 | −0.66 |
| 65.1 (7.2) | 43.5 | −1.31 | 0.013 |
| 63.7 (8.6) | 44.4 | −1.58 | <0.001 |
| Mizuno Y. et al. [2] | 2013 | 373 | 65.8 (8.6) | 47.2 | −0.23 |
| 66.1 (8.6) | 33.3 | −0.99 | 0.003 |
| 65.7 (9.0) | 52.0 | −0.96 | 0.003 |