| Responders |
| Non-responders |
| p | |||
| Sex (Male: Female) n | 5 | 16 |
| 6 | 4 |
| 0.049* |
| Mean | Std. Deviation |
| Mean | Std. Deviation |
| p | |
| Age at onset | 51.9 | 12.3 |
| 61.5 | 10.5 |
| 0.043* |
| Age at examination | 62.9 | 10.4 |
| 70.6 | 8.0 |
| 0.049* |
| Disease duration (year) | 9.1 | 6.2 |
| 9.1 | 6.2 |
| 0.429 |
| Age at onset of wearing off | 59.3 | 11.0 |
| 65.6 | 9.4 |
| 0.127 |
| Wearing off duration (year) | 3.7 | 3.7 |
| 4.1 | 4.7 |
| 0.774 |
| Age at onset of dyskinesia | 57.9 | 8.8 |
| 67.6 | 7.2 |
| 0.025* |
| Dyskinesia duration (year) | 4.2 | 4.3 |
| 3.7 | 5.6 |
| 0.468 |
| Daily cups of coffee | 1.1 | 1.2 |
| 0.5 | 0.6 |
| 0.105 |
| Daily levodopa (mg) | 538.1 | 254.9 |
| 585.0 | 168.4 |
| 0.414 |
| Levodopa cumulative dose (g) | 1163.5 | 1141.4 |
| 1023.7 | 1453.9 |
| 0.772 |
| Levodopa equivalent dose (mg) [6] | 802.5 | 320.1 |
| 829.4 | 294.7 |
| 0.825 |
| Frequency of the levodopa | 4.6 | 1.4 |
| 4.9 | 1.7 |
| 0.569 |
| On time (hour) | 11.8 | 3.6 |
| 10.0 | 3.7 |
| 0.236 |
| Off time (hour) | 5.3 | 3.6 |
| 7.1 | 2.1 |
| 0.216 |
| Sleeping time (hour) | 6.8 | 1.9 |
| 6.9 | 2.3 |
| 0.886 |
| Total UPDRS | 29.2 | 22.4 |
| 35.4 | 26.1 |
| 0.744 |
| UPDRS part II | 7.9 | 7.3 |
| 9.6 | 7.1 |
| 0.617 |
| UPDRS part III | 16.9 | 15.6 |
| 21.3 | 18.4 |
| 0.763 |
| UPDRS part IV | 3.5 | 1.8 |
| 4.0 | 2.0 |
| 0.337 |
| Epworth sleepiness scale | 4.5 | 2.7 |
| 11.2 | 6.7 |
| 0.001** |
| The change from the baseline |
|
| |||||
| On time (hour) | 2.8 | 3.5 |
| 0.0 | 0.6 |
| 0.073 |
| Off time (hour) | −2.8 | 3.6 |
| −0.3 | 0.9 |
| 0.105 |
| Total UPDRS | −3.9 | 7.0 |
| −2.9 | 6.1 |
| 0.744 |
| UPDRS part II | −1.2 | 2.4 |
| −1.7 | 1.9 |
| 0.617 |
| UPDRS part III | −2.6 | 6.5 |
| −1.7 | 5.0 |
| 0.763 |
| UPDRS part IV | −0.3 | 0.9 |
| 0.6 | 2.0 |
| 0.337 |
| Epworth sleepiness scale | 0.0 | 1.8 |
| −1.8 | 4.7 |
| 0.231 |