| Acquired Resistance to EGFR-TKI | Acquired Resistance to ALK-TKI |
| On target | On target |
| EGFR C797S | L1196M |
| EGFR ligand overexpression | G1202R |
| EGFR G724S, G797/797 |
|
| EGFR L792, L718/G719 |
|
| EGFR T790M |
|
| Bypass tracks | Bypass tracks |
| MET amplification | MET amplification |
| RET fusion | EGFR pathway |
| FGFR3 fusion | SRC |
| BRAF mutation/fusion | IGF-1R |
| KRAS amplification |
|
| HER2 amplification |
|
| Histologic transformation | Histologic transformation |
| Adenocarcinoma to squamous cell carcinoma | Transformation to small cell lung cancer |