Dyspnea

117 (28.8)

Chest pain

81 (20)

Performance status (PS)

0 - 1

264 (65.2)

2

89 (22)

3 - 4

52 (12.9)

Histological type

Adenocarcinoma

241 (59.5)

Squamous cell carcinoma

91 (22.5)

Undifferentiated carcinoma

54 (13.3)

Neuroendocrine carcinoma

11 (2.7)

Sarcomatoid carcinoma

5 (1.3)

Carcinoid tumor

3 (0.7)

Tumor size

T1

4 (1)

T2

28 (7)

T3

122 (30)

T4

251 (62)

Lymph node involvement

N1

146 (36)

N2

117 (29)

N3

142 (35)

Metastatic sites

Lung

204 (50.4)

Bone

132 (32.6)

Pleura

89 (22)

Brain

86 (21.2)

Liver

71 (17.5)

Number of metastatic sites

1

247 (61)

>1

158 (39)

Biological disturbances

Anemia

238 (58.8)

Hyperleukocytosis

186 (45.9)

Thrombocytosis

56 (13.8)

Hypoalbuminemia

201 (49.6)

High LDH level

139 (34.3)

High LAP rate

117 (29)

High level of CRP (>10 ng/l)

322 (79.5)

Hypercalcemia

16 (4)

First line treatment

Conventional chemotherapy

353 (87.1)

TKI anti-EGFR

10 (2.5)

Supportive care

42 (10.4)

Conventional chemotherapy

Platinum based doublet

247 (70)

Platinum based doublet + BEVACIZUMAB

46 (13)

NAVELBINE (monotherapy)

60 (17)