| Dyspnea | 117 (28.8) |
Chest pain | 81 (20) | |
Performance status (PS) | 0 - 1 | 264 (65.2) |
2 | 89 (22) | |
3 - 4 | 52 (12.9) | |
Histological type | Adenocarcinoma | 241 (59.5) |
Squamous cell carcinoma | 91 (22.5) | |
Undifferentiated carcinoma | 54 (13.3) | |
Neuroendocrine carcinoma | 11 (2.7) | |
Sarcomatoid carcinoma | 5 (1.3) | |
Carcinoid tumor | 3 (0.7) | |
Tumor size | T1 | 4 (1) |
T2 | 28 (7) | |
T3 | 122 (30) | |
T4 | 251 (62) | |
Lymph node involvement | N1 | 146 (36) |
N2 | 117 (29) | |
N3 | 142 (35) | |
Metastatic sites | Lung | 204 (50.4) |
Bone | 132 (32.6) | |
Pleura | 89 (22) | |
Brain | 86 (21.2) | |
Liver | 71 (17.5) | |
Number of metastatic sites | 1 | 247 (61) |
>1 | 158 (39) | |
Biological disturbances | Anemia | 238 (58.8) |
Hyperleukocytosis | 186 (45.9) | |
Thrombocytosis | 56 (13.8) | |
Hypoalbuminemia | 201 (49.6) | |
High LDH level | 139 (34.3) | |
High LAP rate | 117 (29) | |
High level of CRP (>10 ng/l) | 322 (79.5) | |
Hypercalcemia | 16 (4) | |
First line treatment | Conventional chemotherapy | 353 (87.1) |
TKI anti-EGFR | 10 (2.5) | |
Supportive care | 42 (10.4) | |
Conventional chemotherapy | Platinum based doublet | 247 (70) |
Platinum based doublet + BEVACIZUMAB | 46 (13) | |
NAVELBINE (monotherapy) | 60 (17) |