Mental

symptoms

(21 items)

Pre-chemotherapy

Post-chemotherapy

p value

change

2nd

evaluation

of QOL

(Scores at baseline)

(Scores at 2 weeks)

(%)

Irritability

1.4 ± 0.5

1.5 ± 0.6

0.299

6.1

→

Easily angered

1.9 ± 1.1

1.8 ± 1.2

0.402

−4.3

→

Loss of motivation

2.0 ± 0.8

2.3 ± 1.0

0.193

11.4

↑

No feeling of happiness

2.0 ± 0.9

2.1 ± 0.9

0.367

4.5

→

Nothing to look

forward in life

2.1 ± 0.8

2.6 ± 1.2

0.049

23.3

↑

Daily life is not enjoyable

2.1 ± 1.0

2.5 ± 1.2

0.089

21.2

↑

Loss of confidence

1.8 ± 0.9

2.2 ± 1.1

0.102

20.5

↑

Reluctance to talk with others

2.0 ± 1.0

2.2 ± 1.3

0.218

13.1

↑

Depressed

2.1 ± 1.0

2.3 ± 1.1

0.222

10.7

↑

A sense of uselessness

1.9 ± 0.9

2.4 ± 1.2

0.038

29.9

↑

Shallow sleep

1.8 ± 0.7

2.4 ± 1.3

0.031

31.9

↑

Difficulty falling asleep

2.2 ± 1.0

2.4 ± 1.0

0.254

8.7

→

Pessimism

2.3 ± 1.1

2.7 ± 1.2

0.101

18.1

↑

Lapse of memory

2.3 ± 1.1

2.7 ± 1.2

0.097

19.0

↑

Inability of

concentrate

1.8 ± 0.9

2.2 ± 1.2

0.104

20.8

↑

Inability to solve problems

2.4 ± 1.2

2.2 ± 1.0

0.325

−6.0

→

Inability to make

judgements readily

2.1 ± 0.9

2.5 ± 1.2

0.098

18.7

↑

Inability to sleep because of worries

2.1 ± 1.1

2.1 ± 0.8

0.495

0.2

→

A sense of tension

2.0 ± 0.9

2.2 ± 1.0

0.327

6.4

→

Feeling of anxiety for no special reason

2.3 ± 1.1

2.5 ± 1.1

0.339

5.8

→

A vague feeling of fear

2.4 ± 0.9

2.3 ± 1.1

0.404

-3.0

→