| Toxicity | Grade 1 | Grade 2 | Grade 3 | Grade 4 |
| Nausea | 16 | 0 | 0 | 0 |
| Vomiting | 1 | 0 | 0 | 0 |
| Anorexia | 13 | 2 | 0 | 0 |
| Fatigue | 13 | 2 | 0 | 0 |
| Diarrhea | 2 | 0 | 0 | 0 |
| Constipation | 2 | 0 | 0 | 0 |
| ALT/AST | 0 | 0 | 0 | 0 |
| Creatinine | 0 | 0 | 0 | 0 |
| Neuropathy | 0 | 0 | 0 | 0 |
| Pain, joint | 1 | 0 | 0 | 0 |
| Pain, muscle | 1 | 0 | 0 | 0 |
| Skin rash | 1 | 0 | 0 | 0 |
| Alopecia | 1 | 5 | 0 | 0 |
| Infection | 0 | 0 | 0 | 0 |
| Fever | 5 | 1 | 0 | 0 |
| Others (hearing) | 0 | 1 | 0 | 0 |